Increase in both CEA and CA19-9 in sera is an independent prognostic indicator in colorectal carcinoma

Tadahiro Nozoe, Tatsuya Rikimaru, Emiko Mori, Toshiro Okuyama, Ikuo Takahashi

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background and Objectives: Carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9) are well known to be the most common tumor markers of colorectal carcinomas. However, the significance of increase in these markers to predict the prognosis of the patients remains a problem for debate. Methods: One hundred three patients with colorectal carcinoma, who had been treated by resection and reconstruction of digestive tracts were studied. Correlation of preoperative serum value of CEA and CA19-9 with clinicopathologic features including prognosis of the patients was investigated. Results: Preoperative elevation of both of the two markers proved to be an independent prognostic indicator, however, an elevation of only one of the two markers did not obtain a prognostic significance. Conclusions: Combined data of preoperative increase in CEA and CA19-9 in sera can provide a powerful and useful information to predict prognosis of patients with colorectal carcinoma.

Original languageEnglish
Pages (from-to)132-137
Number of pages6
JournalJournal of Surgical Oncology
Volume94
Issue number2
DOIs
Publication statusPublished - Aug 1 2006

Fingerprint

Carcinoembryonic Antigen
Colorectal Neoplasms
Serum
Tumor Biomarkers
Gastrointestinal Tract
Carbohydrates
Antigens

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Increase in both CEA and CA19-9 in sera is an independent prognostic indicator in colorectal carcinoma. / Nozoe, Tadahiro; Rikimaru, Tatsuya; Mori, Emiko; Okuyama, Toshiro; Takahashi, Ikuo.

In: Journal of Surgical Oncology, Vol. 94, No. 2, 01.08.2006, p. 132-137.

Research output: Contribution to journalArticle

Nozoe, Tadahiro ; Rikimaru, Tatsuya ; Mori, Emiko ; Okuyama, Toshiro ; Takahashi, Ikuo. / Increase in both CEA and CA19-9 in sera is an independent prognostic indicator in colorectal carcinoma. In: Journal of Surgical Oncology. 2006 ; Vol. 94, No. 2. pp. 132-137.
@article{c7e76981645b449d8e3c913f07ef1c35,
title = "Increase in both CEA and CA19-9 in sera is an independent prognostic indicator in colorectal carcinoma",
abstract = "Background and Objectives: Carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9) are well known to be the most common tumor markers of colorectal carcinomas. However, the significance of increase in these markers to predict the prognosis of the patients remains a problem for debate. Methods: One hundred three patients with colorectal carcinoma, who had been treated by resection and reconstruction of digestive tracts were studied. Correlation of preoperative serum value of CEA and CA19-9 with clinicopathologic features including prognosis of the patients was investigated. Results: Preoperative elevation of both of the two markers proved to be an independent prognostic indicator, however, an elevation of only one of the two markers did not obtain a prognostic significance. Conclusions: Combined data of preoperative increase in CEA and CA19-9 in sera can provide a powerful and useful information to predict prognosis of patients with colorectal carcinoma.",
author = "Tadahiro Nozoe and Tatsuya Rikimaru and Emiko Mori and Toshiro Okuyama and Ikuo Takahashi",
year = "2006",
month = "8",
day = "1",
doi = "10.1002/jso.20577",
language = "English",
volume = "94",
pages = "132--137",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Increase in both CEA and CA19-9 in sera is an independent prognostic indicator in colorectal carcinoma

AU - Nozoe, Tadahiro

AU - Rikimaru, Tatsuya

AU - Mori, Emiko

AU - Okuyama, Toshiro

AU - Takahashi, Ikuo

PY - 2006/8/1

Y1 - 2006/8/1

N2 - Background and Objectives: Carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9) are well known to be the most common tumor markers of colorectal carcinomas. However, the significance of increase in these markers to predict the prognosis of the patients remains a problem for debate. Methods: One hundred three patients with colorectal carcinoma, who had been treated by resection and reconstruction of digestive tracts were studied. Correlation of preoperative serum value of CEA and CA19-9 with clinicopathologic features including prognosis of the patients was investigated. Results: Preoperative elevation of both of the two markers proved to be an independent prognostic indicator, however, an elevation of only one of the two markers did not obtain a prognostic significance. Conclusions: Combined data of preoperative increase in CEA and CA19-9 in sera can provide a powerful and useful information to predict prognosis of patients with colorectal carcinoma.

AB - Background and Objectives: Carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9) are well known to be the most common tumor markers of colorectal carcinomas. However, the significance of increase in these markers to predict the prognosis of the patients remains a problem for debate. Methods: One hundred three patients with colorectal carcinoma, who had been treated by resection and reconstruction of digestive tracts were studied. Correlation of preoperative serum value of CEA and CA19-9 with clinicopathologic features including prognosis of the patients was investigated. Results: Preoperative elevation of both of the two markers proved to be an independent prognostic indicator, however, an elevation of only one of the two markers did not obtain a prognostic significance. Conclusions: Combined data of preoperative increase in CEA and CA19-9 in sera can provide a powerful and useful information to predict prognosis of patients with colorectal carcinoma.

UR - http://www.scopus.com/inward/record.url?scp=33747113107&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33747113107&partnerID=8YFLogxK

U2 - 10.1002/jso.20577

DO - 10.1002/jso.20577

M3 - Article

C2 - 16847905

AN - SCOPUS:33747113107

VL - 94

SP - 132

EP - 137

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 2

ER -