Increase in both CEA and CA19-9 in sera is an independent prognostic indicator in colorectal carcinoma

Tadahiro Nozoe, Tatsuya Rikimaru, Emiko Mori, Toshiro Okuyama, Ikuo Takahashi

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

Background and Objectives: Carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9) are well known to be the most common tumor markers of colorectal carcinomas. However, the significance of increase in these markers to predict the prognosis of the patients remains a problem for debate. Methods: One hundred three patients with colorectal carcinoma, who had been treated by resection and reconstruction of digestive tracts were studied. Correlation of preoperative serum value of CEA and CA19-9 with clinicopathologic features including prognosis of the patients was investigated. Results: Preoperative elevation of both of the two markers proved to be an independent prognostic indicator, however, an elevation of only one of the two markers did not obtain a prognostic significance. Conclusions: Combined data of preoperative increase in CEA and CA19-9 in sera can provide a powerful and useful information to predict prognosis of patients with colorectal carcinoma.

Original languageEnglish
Pages (from-to)132-137
Number of pages6
JournalJournal of Surgical Oncology
Volume94
Issue number2
DOIs
Publication statusPublished - Aug 1 2006

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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