Increase of CD4+TNFα+IL-2-T cells in cerebrospinal fluid of multiple sclerosis patients

N. Shi, Y. Kawano, T. Matsuoka, F. J. Mei, T. Ishizu, Y. Ohyagi, J. Kira

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Intracellular production of TNFα and IL-2 after stimulation with phorbol myristate/ionomycin was flowcytometrically measured in CD4+ T cells from peripheral blood (PB) and cerebrospinal fluid (CSF) of 29 patients with multiple sclerosis (MS), and 16 with other inflammatory and 41 with other non-inflammatory neurological diseases. In CSF, the percentages of CD4+ TNFα+IL-2-T cells were significantly higher in patients with MS than either of the controls, whereas no difference was found in CD4+TNFα+IL-2+T or CD4+TNFα-IL-2+T cells. The increase was more pronounced at relapse than in remission. No significant change was detected in PB. These findings suggested that CD4+TNFα+IL-2-T cells are intrathecally upregulated in MS.

Original languageEnglish
Pages (from-to)120-123
Number of pages4
JournalMultiple Sclerosis
Issue number1
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology


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