Increased 8-oxo-dGTPase in the mitochondria of substantia nigral neurons in Parkinson's disease

Hideki Shimura-Miura, Nobutaka Hattori, Dongchon Kang, Ken ichi Miyako, Yusaku Nakabeppu, Yoshikuni Mizuno

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Abstract

There is growing evidence for the involvement of oxidative stress and mitochondrial respiratory failure in nigral neuronal death in Parkinson's disease (PD). We report increased immunoreactivity of 8-oxo-dGTPase (8-oxo-7, 8-dihydrodeoxyguanosine triphosphatase [hMT'H1]), an enzyme known to play an important role in controlling spontaneous mutagenesis, and 8-oxo-7, 8- deoxyguanosine (8-oxo-dG) in the mitochondria of the substantia nigra of 6 PD patients. Our results suggest that hMTH1 might be a rueful marker of oxidative stress and can be used to explore the relation between such oxidative stress and genomic instability.

Original languageEnglish
Pages (from-to)920-924
Number of pages5
JournalAnnals of Neurology
Volume46
Issue number6
DOIs
Publication statusPublished - Dec 17 1999

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All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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