Increased 8-oxo-dGTPase in the mitochondria of substantia nigral neurons in Parkinson's disease

Hideki Shimura-Miura, Nobutaka Hattori, Dongchon Kang, Ken ichi Miyako, Yusaku Nakabeppu, Yoshikuni Mizuno

Research output: Contribution to journalArticlepeer-review

140 Citations (Scopus)

Abstract

There is growing evidence for the involvement of oxidative stress and mitochondrial respiratory failure in nigral neuronal death in Parkinson's disease (PD). We report increased immunoreactivity of 8-oxo-dGTPase (8-oxo-7, 8-dihydrodeoxyguanosine triphosphatase [hMT'H1]), an enzyme known to play an important role in controlling spontaneous mutagenesis, and 8-oxo-7, 8- deoxyguanosine (8-oxo-dG) in the mitochondria of the substantia nigra of 6 PD patients. Our results suggest that hMTH1 might be a rueful marker of oxidative stress and can be used to explore the relation between such oxidative stress and genomic instability.

Original languageEnglish
Pages (from-to)920-924
Number of pages5
JournalAnnals of Neurology
Volume46
Issue number6
DOIs
Publication statusPublished - 1999

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Increased 8-oxo-dGTPase in the mitochondria of substantia nigral neurons in Parkinson's disease'. Together they form a unique fingerprint.

Cite this