There is growing evidence for the involvement of oxidative stress and mitochondrial respiratory failure in nigral neuronal death in Parkinson's disease (PD). We report increased immunoreactivity of 8-oxo-dGTPase (8-oxo-7, 8-dihydrodeoxyguanosine triphosphatase [hMT'H1]), an enzyme known to play an important role in controlling spontaneous mutagenesis, and 8-oxo-7, 8- deoxyguanosine (8-oxo-dG) in the mitochondria of the substantia nigra of 6 PD patients. Our results suggest that hMTH1 might be a rueful marker of oxidative stress and can be used to explore the relation between such oxidative stress and genomic instability.
|Number of pages||5|
|Journal||Annals of Neurology|
|Publication status||Published - Dec 17 1999|
All Science Journal Classification (ASJC) codes
- Clinical Neurology