Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects

Michiko Itoh, Takayoshi Suganami, Noriko Satoh, Kanami Tanimoto-Koyama, Xunmei Yuan, Miyako Tanaka, Hiroyuki Kawano, Takashi Yano, Seiichiro Aoe, Motohiro Takeya, Akira Shimatsu, Hideshi Kuzuya, Yasutomi Kamei, Yoshihiro Ogawa

Research output: Contribution to journalArticle

209 Citations (Scopus)

Abstract

OBJECTIVES - Fish oil rich in n-3 polyunsaturated fatty acids (PUFAs) or n-3 PUFAs have been shown to reduce the incidence of coronary heart disease. Here we investigated the effect of highly purified eicosapentaenoic acid (EPA) on production of adiponectin, the only established antiatherogenic and antiinflammatory adipocytokine, in rodent models of obesity and human obese subjects. METHODS AND RESULTS - We demonstrated that EPA increases adiponectin secretion in genetically obese ob/ob mice and high-fat diet-induced obese mice. In the in vitro coculture of adipocytes and macrophages, EPA reversed the coculture-induced decrease in adiponectin secretion at least in part through downregulation of tumor necrosis factor-α in macrophages. We also showed significant increase in plasma adiponectin concentrations in human obese subjects after a 3-month treatment with EPA (1.8 g daily). Multivariate regression analysis revealed that EPA treatment is the only independent determinant of plasma adiponectin concentrations. CONCLUSION - This study demonstrates that EPA increases adiponectin secretion in rodent models of obesity and human obese subjects, possibly through the improvement of the inflammatory changes in obese adipose tissue. Because EPA has reduced the risk of major coronary events in a large-scale, prospective, randomized clinical trial, this study provides important insight into its therapeutic implication in obesity-related metabolic sequelae.

Original languageEnglish
Pages (from-to)1918-1925
Number of pages8
JournalArteriosclerosis, thrombosis, and vascular biology
Volume27
Issue number9
DOIs
Publication statusPublished - Sep 1 2007
Externally publishedYes

Fingerprint

Eicosapentaenoic Acid
Adiponectin
Rodentia
Obesity
Omega-3 Fatty Acids
Coculture Techniques
Macrophages
Obese Mice
Adipokines
Fish Oils
High Fat Diet
Adipocytes
Coronary Disease
Adipose Tissue
Anti-Inflammatory Agents
Down-Regulation
Multivariate Analysis
Randomized Controlled Trials
Tumor Necrosis Factor-alpha
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects. / Itoh, Michiko; Suganami, Takayoshi; Satoh, Noriko; Tanimoto-Koyama, Kanami; Yuan, Xunmei; Tanaka, Miyako; Kawano, Hiroyuki; Yano, Takashi; Aoe, Seiichiro; Takeya, Motohiro; Shimatsu, Akira; Kuzuya, Hideshi; Kamei, Yasutomi; Ogawa, Yoshihiro.

In: Arteriosclerosis, thrombosis, and vascular biology, Vol. 27, No. 9, 01.09.2007, p. 1918-1925.

Research output: Contribution to journalArticle

Itoh, M, Suganami, T, Satoh, N, Tanimoto-Koyama, K, Yuan, X, Tanaka, M, Kawano, H, Yano, T, Aoe, S, Takeya, M, Shimatsu, A, Kuzuya, H, Kamei, Y & Ogawa, Y 2007, 'Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects', Arteriosclerosis, thrombosis, and vascular biology, vol. 27, no. 9, pp. 1918-1925. https://doi.org/10.1161/ATVBAHA.106.136853
Itoh, Michiko ; Suganami, Takayoshi ; Satoh, Noriko ; Tanimoto-Koyama, Kanami ; Yuan, Xunmei ; Tanaka, Miyako ; Kawano, Hiroyuki ; Yano, Takashi ; Aoe, Seiichiro ; Takeya, Motohiro ; Shimatsu, Akira ; Kuzuya, Hideshi ; Kamei, Yasutomi ; Ogawa, Yoshihiro. / Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects. In: Arteriosclerosis, thrombosis, and vascular biology. 2007 ; Vol. 27, No. 9. pp. 1918-1925.
@article{e229f5a9255e4d7fa527c07a82e53941,
title = "Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects",
abstract = "OBJECTIVES - Fish oil rich in n-3 polyunsaturated fatty acids (PUFAs) or n-3 PUFAs have been shown to reduce the incidence of coronary heart disease. Here we investigated the effect of highly purified eicosapentaenoic acid (EPA) on production of adiponectin, the only established antiatherogenic and antiinflammatory adipocytokine, in rodent models of obesity and human obese subjects. METHODS AND RESULTS - We demonstrated that EPA increases adiponectin secretion in genetically obese ob/ob mice and high-fat diet-induced obese mice. In the in vitro coculture of adipocytes and macrophages, EPA reversed the coculture-induced decrease in adiponectin secretion at least in part through downregulation of tumor necrosis factor-α in macrophages. We also showed significant increase in plasma adiponectin concentrations in human obese subjects after a 3-month treatment with EPA (1.8 g daily). Multivariate regression analysis revealed that EPA treatment is the only independent determinant of plasma adiponectin concentrations. CONCLUSION - This study demonstrates that EPA increases adiponectin secretion in rodent models of obesity and human obese subjects, possibly through the improvement of the inflammatory changes in obese adipose tissue. Because EPA has reduced the risk of major coronary events in a large-scale, prospective, randomized clinical trial, this study provides important insight into its therapeutic implication in obesity-related metabolic sequelae.",
author = "Michiko Itoh and Takayoshi Suganami and Noriko Satoh and Kanami Tanimoto-Koyama and Xunmei Yuan and Miyako Tanaka and Hiroyuki Kawano and Takashi Yano and Seiichiro Aoe and Motohiro Takeya and Akira Shimatsu and Hideshi Kuzuya and Yasutomi Kamei and Yoshihiro Ogawa",
year = "2007",
month = "9",
day = "1",
doi = "10.1161/ATVBAHA.106.136853",
language = "English",
volume = "27",
pages = "1918--1925",
journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",
issn = "1079-5642",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects

AU - Itoh, Michiko

AU - Suganami, Takayoshi

AU - Satoh, Noriko

AU - Tanimoto-Koyama, Kanami

AU - Yuan, Xunmei

AU - Tanaka, Miyako

AU - Kawano, Hiroyuki

AU - Yano, Takashi

AU - Aoe, Seiichiro

AU - Takeya, Motohiro

AU - Shimatsu, Akira

AU - Kuzuya, Hideshi

AU - Kamei, Yasutomi

AU - Ogawa, Yoshihiro

PY - 2007/9/1

Y1 - 2007/9/1

N2 - OBJECTIVES - Fish oil rich in n-3 polyunsaturated fatty acids (PUFAs) or n-3 PUFAs have been shown to reduce the incidence of coronary heart disease. Here we investigated the effect of highly purified eicosapentaenoic acid (EPA) on production of adiponectin, the only established antiatherogenic and antiinflammatory adipocytokine, in rodent models of obesity and human obese subjects. METHODS AND RESULTS - We demonstrated that EPA increases adiponectin secretion in genetically obese ob/ob mice and high-fat diet-induced obese mice. In the in vitro coculture of adipocytes and macrophages, EPA reversed the coculture-induced decrease in adiponectin secretion at least in part through downregulation of tumor necrosis factor-α in macrophages. We also showed significant increase in plasma adiponectin concentrations in human obese subjects after a 3-month treatment with EPA (1.8 g daily). Multivariate regression analysis revealed that EPA treatment is the only independent determinant of plasma adiponectin concentrations. CONCLUSION - This study demonstrates that EPA increases adiponectin secretion in rodent models of obesity and human obese subjects, possibly through the improvement of the inflammatory changes in obese adipose tissue. Because EPA has reduced the risk of major coronary events in a large-scale, prospective, randomized clinical trial, this study provides important insight into its therapeutic implication in obesity-related metabolic sequelae.

AB - OBJECTIVES - Fish oil rich in n-3 polyunsaturated fatty acids (PUFAs) or n-3 PUFAs have been shown to reduce the incidence of coronary heart disease. Here we investigated the effect of highly purified eicosapentaenoic acid (EPA) on production of adiponectin, the only established antiatherogenic and antiinflammatory adipocytokine, in rodent models of obesity and human obese subjects. METHODS AND RESULTS - We demonstrated that EPA increases adiponectin secretion in genetically obese ob/ob mice and high-fat diet-induced obese mice. In the in vitro coculture of adipocytes and macrophages, EPA reversed the coculture-induced decrease in adiponectin secretion at least in part through downregulation of tumor necrosis factor-α in macrophages. We also showed significant increase in plasma adiponectin concentrations in human obese subjects after a 3-month treatment with EPA (1.8 g daily). Multivariate regression analysis revealed that EPA treatment is the only independent determinant of plasma adiponectin concentrations. CONCLUSION - This study demonstrates that EPA increases adiponectin secretion in rodent models of obesity and human obese subjects, possibly through the improvement of the inflammatory changes in obese adipose tissue. Because EPA has reduced the risk of major coronary events in a large-scale, prospective, randomized clinical trial, this study provides important insight into its therapeutic implication in obesity-related metabolic sequelae.

UR - http://www.scopus.com/inward/record.url?scp=34548274430&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548274430&partnerID=8YFLogxK

U2 - 10.1161/ATVBAHA.106.136853

DO - 10.1161/ATVBAHA.106.136853

M3 - Article

VL - 27

SP - 1918

EP - 1925

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

SN - 1079-5642

IS - 9

ER -