Abstract
To clarify the mechanism of brain and spinal cord impairment in amyotrophic lateral sclerosis (ALS), we measured the cerebrospinal fluid (CSF) levels of substance P (SP) in 11 patients with sporadic ALS. Findings were compared with those obtained in controls and diseased controls. The CSF SP levels of patients with ALS, and particularly in patients with a disease duration of less than 2.5 years, were significantly higher than those in controls. These findings strongly suggested that SP may play an important role in the pathophysiology of ALS.
| Original language | English |
|---|---|
| Pages (from-to) | 943-948 |
| Number of pages | 6 |
| Journal | Journal of Neural Transmission |
| Volume | 106 |
| Issue number | 9-10 |
| DOIs | |
| Publication status | Published - Nov 17 1999 |
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All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
Increased cerebrospinal fluid levels of substance P in patients with amyotrophic lateral sclerosis. / Matsuishi, T.; Nagamitsu, S.; Shoji, H.; Itoh, M.; Takashima, S.; Iwaki, Toru; Shida, N.; Yamashita, Y.; Sakai, T.; Kato, H.
In: Journal of Neural Transmission, Vol. 106, No. 9-10, 17.11.1999, p. 943-948.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased cerebrospinal fluid levels of substance P in patients with amyotrophic lateral sclerosis
AU - Matsuishi, T.
AU - Nagamitsu, S.
AU - Shoji, H.
AU - Itoh, M.
AU - Takashima, S.
AU - Iwaki, Toru
AU - Shida, N.
AU - Yamashita, Y.
AU - Sakai, T.
AU - Kato, H.
PY - 1999/11/17
Y1 - 1999/11/17
N2 - To clarify the mechanism of brain and spinal cord impairment in amyotrophic lateral sclerosis (ALS), we measured the cerebrospinal fluid (CSF) levels of substance P (SP) in 11 patients with sporadic ALS. Findings were compared with those obtained in controls and diseased controls. The CSF SP levels of patients with ALS, and particularly in patients with a disease duration of less than 2.5 years, were significantly higher than those in controls. These findings strongly suggested that SP may play an important role in the pathophysiology of ALS.
AB - To clarify the mechanism of brain and spinal cord impairment in amyotrophic lateral sclerosis (ALS), we measured the cerebrospinal fluid (CSF) levels of substance P (SP) in 11 patients with sporadic ALS. Findings were compared with those obtained in controls and diseased controls. The CSF SP levels of patients with ALS, and particularly in patients with a disease duration of less than 2.5 years, were significantly higher than those in controls. These findings strongly suggested that SP may play an important role in the pathophysiology of ALS.
UR - http://www.scopus.com/inward/record.url?scp=0032749037&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032749037&partnerID=8YFLogxK
U2 - 10.1007/s007020050214
DO - 10.1007/s007020050214
M3 - Article
C2 - 10599876
AN - SCOPUS:0032749037
VL - 106
SP - 943
EP - 948
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
SN - 0300-9564
IS - 9-10
ER -