Increased cerebrospinal fluid levels of substance P in patients with amyotrophic lateral sclerosis

T. Matsuishi, S. Nagamitsu, H. Shoji, M. Itoh, S. Takashima, Toru Iwaki, N. Shida, Y. Yamashita, T. Sakai, H. Kato

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Abstract

To clarify the mechanism of brain and spinal cord impairment in amyotrophic lateral sclerosis (ALS), we measured the cerebrospinal fluid (CSF) levels of substance P (SP) in 11 patients with sporadic ALS. Findings were compared with those obtained in controls and diseased controls. The CSF SP levels of patients with ALS, and particularly in patients with a disease duration of less than 2.5 years, were significantly higher than those in controls. These findings strongly suggested that SP may play an important role in the pathophysiology of ALS.

Original languageEnglish
Pages (from-to)943-948
Number of pages6
JournalJournal of Neural Transmission
Volume106
Issue number9-10
DOIs
Publication statusPublished - Nov 17 1999

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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    Matsuishi, T., Nagamitsu, S., Shoji, H., Itoh, M., Takashima, S., Iwaki, T., Shida, N., Yamashita, Y., Sakai, T., & Kato, H. (1999). Increased cerebrospinal fluid levels of substance P in patients with amyotrophic lateral sclerosis. Journal of Neural Transmission, 106(9-10), 943-948. https://doi.org/10.1007/s007020050214