Abstract
To clarify the mechanism of brain and spinal cord impairment in amyotrophic lateral sclerosis (ALS), we measured the cerebrospinal fluid (CSF) levels of substance P (SP) in 11 patients with sporadic ALS. Findings were compared with those obtained in controls and diseased controls. The CSF SP levels of patients with ALS, and particularly in patients with a disease duration of less than 2.5 years, were significantly higher than those in controls. These findings strongly suggested that SP may play an important role in the pathophysiology of ALS.
| Original language | English |
|---|---|
| Pages (from-to) | 943-948 |
| Number of pages | 6 |
| Journal | Journal of Neural Transmission |
| Volume | 106 |
| Issue number | 9-10 |
| DOIs | |
| Publication status | Published - Nov 17 1999 |
All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry
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Matsuishi, T., Nagamitsu, S., Shoji, H., Itoh, M., Takashima, S., Iwaki, T., Shida, N., Yamashita, Y., Sakai, T., & Kato, H. (1999). Increased cerebrospinal fluid levels of substance P in patients with amyotrophic lateral sclerosis. Journal of Neural Transmission, 106(9-10), 943-948. https://doi.org/10.1007/s007020050214