Increased cerebrospinal fluid levels of substance P in patients with amyotrophic lateral sclerosis

T. Matsuishi, S. Nagamitsu, H. Shoji, M. Itoh, S. Takashima, Toru Iwaki, N. Shida, Y. Yamashita, T. Sakai, H. Kato

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

To clarify the mechanism of brain and spinal cord impairment in amyotrophic lateral sclerosis (ALS), we measured the cerebrospinal fluid (CSF) levels of substance P (SP) in 11 patients with sporadic ALS. Findings were compared with those obtained in controls and diseased controls. The CSF SP levels of patients with ALS, and particularly in patients with a disease duration of less than 2.5 years, were significantly higher than those in controls. These findings strongly suggested that SP may play an important role in the pathophysiology of ALS.

Original languageEnglish
Pages (from-to)943-948
Number of pages6
JournalJournal of Neural Transmission
Volume106
Issue number9-10
DOIs
Publication statusPublished - Nov 17 1999

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Amyotrophic Lateral Sclerosis
Substance P
Cerebrospinal Fluid
Spinal Cord
Brain

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Increased cerebrospinal fluid levels of substance P in patients with amyotrophic lateral sclerosis. / Matsuishi, T.; Nagamitsu, S.; Shoji, H.; Itoh, M.; Takashima, S.; Iwaki, Toru; Shida, N.; Yamashita, Y.; Sakai, T.; Kato, H.

In: Journal of Neural Transmission, Vol. 106, No. 9-10, 17.11.1999, p. 943-948.

Research output: Contribution to journalArticle

Matsuishi, T, Nagamitsu, S, Shoji, H, Itoh, M, Takashima, S, Iwaki, T, Shida, N, Yamashita, Y, Sakai, T & Kato, H 1999, 'Increased cerebrospinal fluid levels of substance P in patients with amyotrophic lateral sclerosis', Journal of Neural Transmission, vol. 106, no. 9-10, pp. 943-948. https://doi.org/10.1007/s007020050214
Matsuishi, T. ; Nagamitsu, S. ; Shoji, H. ; Itoh, M. ; Takashima, S. ; Iwaki, Toru ; Shida, N. ; Yamashita, Y. ; Sakai, T. ; Kato, H. / Increased cerebrospinal fluid levels of substance P in patients with amyotrophic lateral sclerosis. In: Journal of Neural Transmission. 1999 ; Vol. 106, No. 9-10. pp. 943-948.
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