Increased copy number of the gene encoding SF3B4 indicates poor prognosis in hepatocellular carcinoma

Tomohiro Iguchi, Takaaki Masuda, Sho Nambara, Shinya Kidogami, Yushi Ogawa, Qingjiang Hu, Tomoko Saito, Hidenari Hirata, Shotaro Sakimura, Ryutaro Uchi, Naoki Hayashi, Shuhei Ito, Hidetoshi Eguchi, Keishi Sugimachi, Yoshihiko Maehara, Koshi Mimori

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Background/Aim: Defects in alternative splicing contribute to carcinogenesis, cancer progression and chemoresistance. The spliceosome pathway, including SF3B4, a component of spliceosomal complex is suggested to play a role in progression of hepatocellular carcinoma (HCC); however, the clinical relevance of SF3B4 in HCC remains unknown. Patients and Methods: SF3B4 expression was evaluated by real-Time reverse transcription polymerase chain reaction in 72 HCC samples and non-cancerous liver samples. The relationship between the DNA copy number and SF3B4 expression levels was investigated using TCGA datasets. Results: SF3B4 expression was significantly higher in cancerous than in non-cancerous tissues and positively correlated with SF3B4 DNA copy number. High SF3B4 expression is significantly associated with intrahepatic metastasis and poor prognosis. These results were consistent with data from the public datasets. Conclusion: Overexpression of SF3B4, that is due to DNA copy number increase, is suggested to play a role in progression of HCC.

Original languageEnglish
Pages (from-to)2139-2144
Number of pages6
JournalAnticancer research
Volume36
Issue number5
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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