Increased Human Brain Natriuretic Peptide in Congestive Heart Failure

Masashi Mukoyama, Kazuwa Nakao, Yoshihiko Saito, Yoshihiro Ogawa, Kiminori Hosoda, Shin Ichi Suga, Gotaro Shirakami, Michihisa Jougasaki, Hiroo Imura

Research output: Contribution to journalLetter

225 Citations (Scopus)

Abstract

To the Editor: Brain natriuretic peptide (BNP), first isolated from the brains of pigs,1 has a striking similarity to atrial natriuretic peptide (ANP) both in structure and in peripheral and central actions.1 2 3 4 BNP is also a cardiac hormone in pigs5 and rats.6,7 Antiserums against porcine or rat BNP, however, failed to detect BNP-like immunoreactivity in human tissues, indicating the structural diversity of BNP among species. Recently, we isolated human BNP from the atrium and determined its 32-amino-acid sequence.8 We have developed a specific radioimmunoassay for human BNP8 with the use of a monoclonal antibody, modeling it on a radioimmunoassay for.

Original languageEnglish
Pages (from-to)757-758
Number of pages2
JournalNew England Journal of Medicine
Volume323
Issue number11
DOIs
Publication statusPublished - Sep 13 1990
Externally publishedYes

Fingerprint

Brain Natriuretic Peptide
Heart Failure
Radioimmunoassay
Atrial Natriuretic Factor
Immune Sera
Swine
Monoclonal Antibodies
Hormones
Amino Acids
Brain

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Mukoyama, M., Nakao, K., Saito, Y., Ogawa, Y., Hosoda, K., Suga, S. I., ... Imura, H. (1990). Increased Human Brain Natriuretic Peptide in Congestive Heart Failure. New England Journal of Medicine, 323(11), 757-758. https://doi.org/10.1056/NEJM199009133231114

Increased Human Brain Natriuretic Peptide in Congestive Heart Failure. / Mukoyama, Masashi; Nakao, Kazuwa; Saito, Yoshihiko; Ogawa, Yoshihiro; Hosoda, Kiminori; Suga, Shin Ichi; Shirakami, Gotaro; Jougasaki, Michihisa; Imura, Hiroo.

In: New England Journal of Medicine, Vol. 323, No. 11, 13.09.1990, p. 757-758.

Research output: Contribution to journalLetter

Mukoyama, M, Nakao, K, Saito, Y, Ogawa, Y, Hosoda, K, Suga, SI, Shirakami, G, Jougasaki, M & Imura, H 1990, 'Increased Human Brain Natriuretic Peptide in Congestive Heart Failure', New England Journal of Medicine, vol. 323, no. 11, pp. 757-758. https://doi.org/10.1056/NEJM199009133231114
Mukoyama, Masashi ; Nakao, Kazuwa ; Saito, Yoshihiko ; Ogawa, Yoshihiro ; Hosoda, Kiminori ; Suga, Shin Ichi ; Shirakami, Gotaro ; Jougasaki, Michihisa ; Imura, Hiroo. / Increased Human Brain Natriuretic Peptide in Congestive Heart Failure. In: New England Journal of Medicine. 1990 ; Vol. 323, No. 11. pp. 757-758.
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AU - Suga, Shin Ichi

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