Increased hyperthermic response with prostaglandin e1 in VX2 liver carcinoma in rabbits

Masaru Morita, Hiroyuki Kuwano, Hiroyuki Matsuda, Masaki Mori, Keizo Sugimachi

Research output: Contribution to journalArticle

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Abstract

Most studies examining the potential of vasoactive drugs to selectively reduce the blood flow in a tumor and to enhance the thermal response to hyperthermia have used tumors growing in muscle tissues. We investigated the effect of prostaglandin E1 on a VX2 liver carcinoma in 95 female Japanese white rabbits. During continuous 20-minute intravenous infusions of prostaglandin E1 at doses of 1, 3, and 5 μg/kg per minute in rabbits with this liver tumor, the mean arterial blood pressure decreased to 81%, 74%, and 51% of initial levels, respectively. In the tumor, regional blood flow was 86%, 70%, and 56% of initial levels, respectively; in the adjacent liver tissue, it was 149%, 110%, and 86% of initial levels, respectively. The tumor and adjacent liver tissues were heated by a micro wave generator, and the liver tissue was kept at 42.0 °C. The average temperature at the center of the tumor, which was 43.0 °C in the absence of prostaglandin E1,increased to 44.3 °C, 44.3 °C, and 44.2 °C when doses of 1, 3, and 5 μg/kg per minute were given, respectively. The therapeutic effect was determined on the basis of the tumor growth ratio (geometric tumor volume 7 days after treatmentivolume at start of treatment). Hyperthermia alone resulted in a small reduction in the tumor growth ratio-from the control value of 11.82 to a value of 9.03. Hyperthermia combined with prostaglandin E1 led to an augmented reduction in tumor growth ratio (4.28, 4.70, and 4.79 during 1, 3, and 5 tg/kg per minute respectively), compared with findings with hyperthermia alone. These results indicate that prostaglandin E1 reduces tumor blood flow, elevates tumor temperature during hyperthermia, and retards tumor growth after local heat treatment. For these reasons, prostaglandin E1 may be an effective adjuvant drug in clinical studies of hyperthermia in liver tumor. [J Natl Cancer Inst 83:1395-1400, 1991]

Original languageEnglish
Pages (from-to)1395-1400
Number of pages6
JournalJournal of the National Cancer Institute
Volume83
Issue number19
DOIs
Publication statusPublished - Oct 2 1991

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Alprostadil
Rabbits
Carcinoma
Liver
Neoplasms
Fever
Growth
Arterial Pressure
Hot Temperature
Temperature
Regional Blood Flow
Therapeutic Uses
Tumor Burden
Intravenous Infusions
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Increased hyperthermic response with prostaglandin e1 in VX2 liver carcinoma in rabbits. / Morita, Masaru; Kuwano, Hiroyuki; Matsuda, Hiroyuki; Mori, Masaki; Sugimachi, Keizo.

In: Journal of the National Cancer Institute, Vol. 83, No. 19, 02.10.1991, p. 1395-1400.

Research output: Contribution to journalArticle

Morita, Masaru ; Kuwano, Hiroyuki ; Matsuda, Hiroyuki ; Mori, Masaki ; Sugimachi, Keizo. / Increased hyperthermic response with prostaglandin e1 in VX2 liver carcinoma in rabbits. In: Journal of the National Cancer Institute. 1991 ; Vol. 83, No. 19. pp. 1395-1400.
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abstract = "Most studies examining the potential of vasoactive drugs to selectively reduce the blood flow in a tumor and to enhance the thermal response to hyperthermia have used tumors growing in muscle tissues. We investigated the effect of prostaglandin E1 on a VX2 liver carcinoma in 95 female Japanese white rabbits. During continuous 20-minute intravenous infusions of prostaglandin E1 at doses of 1, 3, and 5 μg/kg per minute in rabbits with this liver tumor, the mean arterial blood pressure decreased to 81{\%}, 74{\%}, and 51{\%} of initial levels, respectively. In the tumor, regional blood flow was 86{\%}, 70{\%}, and 56{\%} of initial levels, respectively; in the adjacent liver tissue, it was 149{\%}, 110{\%}, and 86{\%} of initial levels, respectively. The tumor and adjacent liver tissues were heated by a micro wave generator, and the liver tissue was kept at 42.0 °C. The average temperature at the center of the tumor, which was 43.0 °C in the absence of prostaglandin E1,increased to 44.3 °C, 44.3 °C, and 44.2 °C when doses of 1, 3, and 5 μg/kg per minute were given, respectively. The therapeutic effect was determined on the basis of the tumor growth ratio (geometric tumor volume 7 days after treatmentivolume at start of treatment). Hyperthermia alone resulted in a small reduction in the tumor growth ratio-from the control value of 11.82 to a value of 9.03. Hyperthermia combined with prostaglandin E1 led to an augmented reduction in tumor growth ratio (4.28, 4.70, and 4.79 during 1, 3, and 5 tg/kg per minute respectively), compared with findings with hyperthermia alone. These results indicate that prostaglandin E1 reduces tumor blood flow, elevates tumor temperature during hyperthermia, and retards tumor growth after local heat treatment. For these reasons, prostaglandin E1 may be an effective adjuvant drug in clinical studies of hyperthermia in liver tumor. [J Natl Cancer Inst 83:1395-1400, 1991]",
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AB - Most studies examining the potential of vasoactive drugs to selectively reduce the blood flow in a tumor and to enhance the thermal response to hyperthermia have used tumors growing in muscle tissues. We investigated the effect of prostaglandin E1 on a VX2 liver carcinoma in 95 female Japanese white rabbits. During continuous 20-minute intravenous infusions of prostaglandin E1 at doses of 1, 3, and 5 μg/kg per minute in rabbits with this liver tumor, the mean arterial blood pressure decreased to 81%, 74%, and 51% of initial levels, respectively. In the tumor, regional blood flow was 86%, 70%, and 56% of initial levels, respectively; in the adjacent liver tissue, it was 149%, 110%, and 86% of initial levels, respectively. The tumor and adjacent liver tissues were heated by a micro wave generator, and the liver tissue was kept at 42.0 °C. The average temperature at the center of the tumor, which was 43.0 °C in the absence of prostaglandin E1,increased to 44.3 °C, 44.3 °C, and 44.2 °C when doses of 1, 3, and 5 μg/kg per minute were given, respectively. The therapeutic effect was determined on the basis of the tumor growth ratio (geometric tumor volume 7 days after treatmentivolume at start of treatment). Hyperthermia alone resulted in a small reduction in the tumor growth ratio-from the control value of 11.82 to a value of 9.03. Hyperthermia combined with prostaglandin E1 led to an augmented reduction in tumor growth ratio (4.28, 4.70, and 4.79 during 1, 3, and 5 tg/kg per minute respectively), compared with findings with hyperthermia alone. These results indicate that prostaglandin E1 reduces tumor blood flow, elevates tumor temperature during hyperthermia, and retards tumor growth after local heat treatment. For these reasons, prostaglandin E1 may be an effective adjuvant drug in clinical studies of hyperthermia in liver tumor. [J Natl Cancer Inst 83:1395-1400, 1991]

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