Increased IL-13-producing T cells in ALS: Positive correlations with disease severity and progression rate

Nan Shi, Yuji Kawano, Takahisa Tateishi, Hitoshi Kikuchi, Manabu Osoegawa, Yasumasa Ohyagi, Jun ichi Kira

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

We measured the intracellular productions of IFNγ, IL-2, IL-4, IL-13 and TNFα in peripheral blood CD4+ and CD8+ T cells from 21 amyotrophic lateral sclerosis (ALS) patients, 14 disease controls (DC) with spinocerebellar degeneration and 16 healthy controls (HC). Only the percentages of CD4+IL-13+ and CD8+IL-13+ T cells were significantly higher in ALS patients than in DC and HC. The CD4+IL-13+ T cell percentages showed a significant negative correlation with the revised ALS functional rating scale scores and significant positive correlation with the disease progression rate, suggesting that IL-13 contributes to ALS.

Original languageEnglish
Pages (from-to)232-235
Number of pages4
JournalJournal of Neuroimmunology
Volume182
Issue number1-2
DOIs
Publication statusPublished - Jan 1 2007

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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    Shi, N., Kawano, Y., Tateishi, T., Kikuchi, H., Osoegawa, M., Ohyagi, Y., & Kira, J. I. (2007). Increased IL-13-producing T cells in ALS: Positive correlations with disease severity and progression rate. Journal of Neuroimmunology, 182(1-2), 232-235. https://doi.org/10.1016/j.jneuroim.2006.10.001