Increased mRNA expression of a novel prostacyclin-stimulating factor in human colon cancer

Fumio Umeda, Yasuhiro Ono, Naotaka Sekiguchi, Toshihiko Hashimoto, Mitsunori Masakado, Kazuhiko Nakamura, Yoshiharu Chijiiwa, Hajime Nawata

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16 Citations (Scopus)

Abstract

We recently cloned a prostacyclin (PGl2)-stimulating factor (PSF), which stimulates PGl2 production by cultured vascular cells. Immunohistochemistry and Northern blot analysis demonstrated that PSF was highly expressed in colon cancer sites compared with normal colon mucosa obtained from the same patient, as well as in cultured adenocarcinoma cell lines compared with cultured normal colon mucosal cell lines. Increased levels of the PSF protein were detected in the culture media of these adenocarcinoma cells compared with levels in the culture media of normal mucosal cells. These results suggest that PSF is closely associated with carcinogenesis of colon mucosa.

Original languageEnglish
Pages (from-to)213-217
Number of pages5
JournalJournal of gastroenterology
Volume33
Issue number2
DOIs
Publication statusPublished - Apr 1 1998

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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    Umeda, F., Ono, Y., Sekiguchi, N., Hashimoto, T., Masakado, M., Nakamura, K., Chijiiwa, Y., & Nawata, H. (1998). Increased mRNA expression of a novel prostacyclin-stimulating factor in human colon cancer. Journal of gastroenterology, 33(2), 213-217. https://doi.org/10.1007/s005350050072