TY - JOUR
T1 - Increased plasma levels of B-type natriuretic peptide in patients with unstable angina
AU - Kikuta, K.
AU - Yasue, H.
AU - Yoshimura, M.
AU - Morita, E.
AU - Sumida, H.
AU - Kato, H.
AU - Kugiyama, K.
AU - Ogawa, H.
AU - Okumura, K.
AU - Ogawa, Y.
AU - Nakao, K.
N1 - Funding Information:
From the aDivision of Cardiology, Kumamoto University School of Medicine, and the bSecond Division, bDepartment of Medicine and Clinical Science, Kyoto University Graduate School of Medicine. Supported in part by a grant from the Ministry of Education and Culture (04263104) and a grant from the Smoking Research Foundation. Received for publication May 22, 1995; accepted Nov. 27, 1995. Reprint requests: Hirofumi Yasue, MD, Division of Cardiology, Kumamoto UNiversity School of Medicine, Honjo 1-1-1, Kumamoto 860, Japan. Copyright © 1996 by Mosby-Year Book, Inc. 0002-8703/96/$5.00 + 0 4/1/72010
PY - 1996
Y1 - 1996
N2 - This study was designed to examine the plasma levels of B-type or brain natriuretic peptide (BNP), as well as A-type or atrial natriuretic peptide (ANP) in patients with unstable angina as compared with those in patients with stable exertional angina end control subjects. We measured the plasma levels of BNP and ANP in 33 patients with unstable angina, 20 patients with stable exertional angina, and 20 control subjects. The plasma levels of BNP were significantly increased in patients with unstable angina compared with those in patients with stable exertional angina and control subjects, respectively (39.5 ± 29.4 pg/ml vs 15.1 ± 8.0 pg/ml; p < 0.01 and 39.5 ± 29.4 pg/ml vs 19.3 ± 6.4 pg/ml; p < 0.01, respectively). On the other hand, there was no significant difference in the plasma levels of ANP among the three groups. Furthermore, in patients with unstable angina, the plasma levels of BNP decreased significantly after the medical treatment (from 39.5 ± 29.4 pg/ml to 15.8 ± 11.0 pg/ml; p < 0.01), whereas the plasma levels of ANP did not change. We conclude that the plasma levels of BNP are increased in the majority of patients with unstable angina and that the increased levels decrease toward normal after treatment.
AB - This study was designed to examine the plasma levels of B-type or brain natriuretic peptide (BNP), as well as A-type or atrial natriuretic peptide (ANP) in patients with unstable angina as compared with those in patients with stable exertional angina end control subjects. We measured the plasma levels of BNP and ANP in 33 patients with unstable angina, 20 patients with stable exertional angina, and 20 control subjects. The plasma levels of BNP were significantly increased in patients with unstable angina compared with those in patients with stable exertional angina and control subjects, respectively (39.5 ± 29.4 pg/ml vs 15.1 ± 8.0 pg/ml; p < 0.01 and 39.5 ± 29.4 pg/ml vs 19.3 ± 6.4 pg/ml; p < 0.01, respectively). On the other hand, there was no significant difference in the plasma levels of ANP among the three groups. Furthermore, in patients with unstable angina, the plasma levels of BNP decreased significantly after the medical treatment (from 39.5 ± 29.4 pg/ml to 15.8 ± 11.0 pg/ml; p < 0.01), whereas the plasma levels of ANP did not change. We conclude that the plasma levels of BNP are increased in the majority of patients with unstable angina and that the increased levels decrease toward normal after treatment.
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U2 - 10.1016/S0002-8703(96)90396-8
DO - 10.1016/S0002-8703(96)90396-8
M3 - Article
C2 - 8701849
AN - SCOPUS:15844428125
VL - 132
SP - 101
EP - 107
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 1 I
ER -