Increased prostaglandin e2 has a positive correlation with plasma calcium during goldfish reproduction

Nobuo Suzuki, Yusuke Maruyama, Masaki Nakano, Atsuhiko Hattori, Masato Honda, Yohei Shimasaki, Toshio Sekiguchi, Hiroyuki Mishima, Shigehito Wada, Ajai K. Srivastav, Kazuichi Hayakawa, Yuji Oshima

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We recently demonstrated that prostaglandin E2 PG¿ increases osteoclastic activity and induces bone resorption in both in vitro and in vivo experiments using goldfish. In the fish reproductive period, the plasma calcium (Ca) level in female teleosts increases remarkably to make vitellogenin, which is a major component of egg protein and a Ca-binding protein. In this period, however, there is no reported relationship between PGE2 and Ca metabolism in fish. To clarify the Ca metabolism in fish reproduction, we examined plasma PGE2 and Ca levels and measured tartrate-resistant acid phosphatase (TRAP) activities as an indicator of osteoclastic activity in goldfish. Plasma PGE2 levels in the reproductive stage significantly increased as compared with those in non-reproductive stages. Also, both plasma Ca and TRAP increased in the reproductive stage. Significant positive correlations were recognized between plasma Ca and the gonad somatic index (r=0.81, p<0.001), plasma Ca and plasma PGE2 levels (r=0.635, p<0.05), and plasma Ca and plasma TRAP activities (r=0.584, p<0.05) from the analysis using samples of both reproductive and nonreproductive stages. Taking these data into consideration, we suggested that PGE, acts on osteoclasts and increases plasma Ca as a result of osteoclastic bone resorption, and we concluded that PGE, is an important hormone in Ca metabolism during fish reproduction.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalJournal of the Faculty of Agriculture, Kyushu University
Volume59
Issue number1
Publication statusPublished - Feb 1 2014

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Agronomy and Crop Science

Fingerprint Dive into the research topics of 'Increased prostaglandin e<sub>2</sub> has a positive correlation with plasma calcium during goldfish reproduction'. Together they form a unique fingerprint.

Cite this