Abstract
Background: Colorectal cancer (CRC) oncogenesis was considered to be determined by interactions between genetic and environmental factors. Specific interacting factors that influence CRC morbidity have yet to be fully investigated. Methods: A multi-institutional collaborative study with 1511 CRC patients and 2098 control subjects was used to compare the odds ratios for the occurrence of polymorphisms at 11 known single nucleotide polymorphisms (SNPs). TaqMan PCR and questionnaires were used to evaluate the effects of environmental exposures. Results: Variants of rs6983267 on 8q24 were the most significant markers of risk for CRC (odds ratio 1.16, 95% confidence interval 1.06-1.27, P = 0.0015). Non-insulindependent diabetes mellitus (DM), a higher body mass index at age 20, and meat consumption were environmental risk factors, whereas a tuna-rich diet and vitamin intake were protective factors. The cohort of rs6983267 SNP major (T) allele at 8q24 and DM had a 1.66-fold higher risk ratio than the cohort of major allele patients without DM. Conclusions: We confirmed that interactions between the genetic background and environmental factors are associated with increased risk for CRC. There is a robust risk of the minor G allele at the 8q24 rs6983267 SNP; however, a major T allele SNP could more clearly reveal a correlation with CRC specifically when DM is present.
| Original language | English |
|---|---|
| Pages (from-to) | 2853-2858 |
| Number of pages | 6 |
| Journal | Annals of Surgical Oncology |
| Volume | 19 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 1 2012 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Oncology
Cite this
Increased risk for CRC in diabetic patients with the nonrisk allele of SNPs at 8q24. / Ishimaru, Shinya; Mimori, Koshi; Yamamoto, Ken; Inoue, Hiroshi; Imoto, Seiya; Kawano, Shuichi; Yamaguchi, Rui; Sato, Tetsuya; Toh, Hiroyuki; Iinuma, Hisae; Maeda, Toyoki; Ishii, Hideshi; Suzuki, Sadao; Tokudome, Shinkan; Watanabe, Masahiko; Tanaka, Jun Ichi; Kudo, Shin Ei; Sugihara, Ken Ichi; Hase, Kazuo; Mochizuki, Hidetaka; Kusunoki, Masato; Yamada, Kazutaka; Shimada, Yasuhiro; Moriya, Yoshihiro; Barnard, Graham F.; Miyano, Satoru; Mori, Masaki.
In: Annals of Surgical Oncology, Vol. 19, No. 9, 01.09.2012, p. 2853-2858.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased risk for CRC in diabetic patients with the nonrisk allele of SNPs at 8q24
AU - Ishimaru, Shinya
AU - Mimori, Koshi
AU - Yamamoto, Ken
AU - Inoue, Hiroshi
AU - Imoto, Seiya
AU - Kawano, Shuichi
AU - Yamaguchi, Rui
AU - Sato, Tetsuya
AU - Toh, Hiroyuki
AU - Iinuma, Hisae
AU - Maeda, Toyoki
AU - Ishii, Hideshi
AU - Suzuki, Sadao
AU - Tokudome, Shinkan
AU - Watanabe, Masahiko
AU - Tanaka, Jun Ichi
AU - Kudo, Shin Ei
AU - Sugihara, Ken Ichi
AU - Hase, Kazuo
AU - Mochizuki, Hidetaka
AU - Kusunoki, Masato
AU - Yamada, Kazutaka
AU - Shimada, Yasuhiro
AU - Moriya, Yoshihiro
AU - Barnard, Graham F.
AU - Miyano, Satoru
AU - Mori, Masaki
PY - 2012/9/1
Y1 - 2012/9/1
N2 - Background: Colorectal cancer (CRC) oncogenesis was considered to be determined by interactions between genetic and environmental factors. Specific interacting factors that influence CRC morbidity have yet to be fully investigated. Methods: A multi-institutional collaborative study with 1511 CRC patients and 2098 control subjects was used to compare the odds ratios for the occurrence of polymorphisms at 11 known single nucleotide polymorphisms (SNPs). TaqMan PCR and questionnaires were used to evaluate the effects of environmental exposures. Results: Variants of rs6983267 on 8q24 were the most significant markers of risk for CRC (odds ratio 1.16, 95% confidence interval 1.06-1.27, P = 0.0015). Non-insulindependent diabetes mellitus (DM), a higher body mass index at age 20, and meat consumption were environmental risk factors, whereas a tuna-rich diet and vitamin intake were protective factors. The cohort of rs6983267 SNP major (T) allele at 8q24 and DM had a 1.66-fold higher risk ratio than the cohort of major allele patients without DM. Conclusions: We confirmed that interactions between the genetic background and environmental factors are associated with increased risk for CRC. There is a robust risk of the minor G allele at the 8q24 rs6983267 SNP; however, a major T allele SNP could more clearly reveal a correlation with CRC specifically when DM is present.
AB - Background: Colorectal cancer (CRC) oncogenesis was considered to be determined by interactions between genetic and environmental factors. Specific interacting factors that influence CRC morbidity have yet to be fully investigated. Methods: A multi-institutional collaborative study with 1511 CRC patients and 2098 control subjects was used to compare the odds ratios for the occurrence of polymorphisms at 11 known single nucleotide polymorphisms (SNPs). TaqMan PCR and questionnaires were used to evaluate the effects of environmental exposures. Results: Variants of rs6983267 on 8q24 were the most significant markers of risk for CRC (odds ratio 1.16, 95% confidence interval 1.06-1.27, P = 0.0015). Non-insulindependent diabetes mellitus (DM), a higher body mass index at age 20, and meat consumption were environmental risk factors, whereas a tuna-rich diet and vitamin intake were protective factors. The cohort of rs6983267 SNP major (T) allele at 8q24 and DM had a 1.66-fold higher risk ratio than the cohort of major allele patients without DM. Conclusions: We confirmed that interactions between the genetic background and environmental factors are associated with increased risk for CRC. There is a robust risk of the minor G allele at the 8q24 rs6983267 SNP; however, a major T allele SNP could more clearly reveal a correlation with CRC specifically when DM is present.
UR - http://www.scopus.com/inward/record.url?scp=84867400939&partnerID=8YFLogxK
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U2 - 10.1245/s10434-012-2278-6
DO - 10.1245/s10434-012-2278-6
M3 - Article
C2 - 22434246
AN - SCOPUS:84867400939
VL - 19
SP - 2853
EP - 2858
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
SN - 1068-9265
IS - 9
ER -