Increased risk for CRC in diabetic patients with the nonrisk allele of SNPs at 8q24

Shinya Ishimaru, Koshi Mimori, Ken Yamamoto, Hiroshi Inoue, Seiya Imoto, Shuichi Kawano, Rui Yamaguchi, Tetsuya Sato, Hiroyuki Toh, Hisae Iinuma, Toyoki Maeda, Hideshi Ishii, Sadao Suzuki, Shinkan Tokudome, Masahiko Watanabe, Jun Ichi Tanaka, Shin Ei Kudo, Ken Ichi Sugihara, Kazuo Hase, Hidetaka MochizukiMasato Kusunoki, Kazutaka Yamada, Yasuhiro Shimada, Yoshihiro Moriya, Graham F. Barnard, Satoru Miyano, Masaki Mori

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Colorectal cancer (CRC) oncogenesis was considered to be determined by interactions between genetic and environmental factors. Specific interacting factors that influence CRC morbidity have yet to be fully investigated. Methods: A multi-institutional collaborative study with 1511 CRC patients and 2098 control subjects was used to compare the odds ratios for the occurrence of polymorphisms at 11 known single nucleotide polymorphisms (SNPs). TaqMan PCR and questionnaires were used to evaluate the effects of environmental exposures. Results: Variants of rs6983267 on 8q24 were the most significant markers of risk for CRC (odds ratio 1.16, 95% confidence interval 1.06-1.27, P = 0.0015). Non-insulindependent diabetes mellitus (DM), a higher body mass index at age 20, and meat consumption were environmental risk factors, whereas a tuna-rich diet and vitamin intake were protective factors. The cohort of rs6983267 SNP major (T) allele at 8q24 and DM had a 1.66-fold higher risk ratio than the cohort of major allele patients without DM. Conclusions: We confirmed that interactions between the genetic background and environmental factors are associated with increased risk for CRC. There is a robust risk of the minor G allele at the 8q24 rs6983267 SNP; however, a major T allele SNP could more clearly reveal a correlation with CRC specifically when DM is present.

Original languageEnglish
Pages (from-to)2853-2858
Number of pages6
JournalAnnals of Surgical Oncology
Volume19
Issue number9
DOIs
Publication statusPublished - Sep 1 2012

Fingerprint

Single Nucleotide Polymorphism
Colorectal Neoplasms
Alleles
Diabetes Mellitus
Odds Ratio
Tuna
Environmental Exposure
Vitamins
Meat
Carcinogenesis
Body Mass Index
Confidence Intervals
Diet
Morbidity
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Increased risk for CRC in diabetic patients with the nonrisk allele of SNPs at 8q24. / Ishimaru, Shinya; Mimori, Koshi; Yamamoto, Ken; Inoue, Hiroshi; Imoto, Seiya; Kawano, Shuichi; Yamaguchi, Rui; Sato, Tetsuya; Toh, Hiroyuki; Iinuma, Hisae; Maeda, Toyoki; Ishii, Hideshi; Suzuki, Sadao; Tokudome, Shinkan; Watanabe, Masahiko; Tanaka, Jun Ichi; Kudo, Shin Ei; Sugihara, Ken Ichi; Hase, Kazuo; Mochizuki, Hidetaka; Kusunoki, Masato; Yamada, Kazutaka; Shimada, Yasuhiro; Moriya, Yoshihiro; Barnard, Graham F.; Miyano, Satoru; Mori, Masaki.

In: Annals of Surgical Oncology, Vol. 19, No. 9, 01.09.2012, p. 2853-2858.

Research output: Contribution to journalArticle

Ishimaru, S, Mimori, K, Yamamoto, K, Inoue, H, Imoto, S, Kawano, S, Yamaguchi, R, Sato, T, Toh, H, Iinuma, H, Maeda, T, Ishii, H, Suzuki, S, Tokudome, S, Watanabe, M, Tanaka, JI, Kudo, SE, Sugihara, KI, Hase, K, Mochizuki, H, Kusunoki, M, Yamada, K, Shimada, Y, Moriya, Y, Barnard, GF, Miyano, S & Mori, M 2012, 'Increased risk for CRC in diabetic patients with the nonrisk allele of SNPs at 8q24', Annals of Surgical Oncology, vol. 19, no. 9, pp. 2853-2858. https://doi.org/10.1245/s10434-012-2278-6
Ishimaru, Shinya ; Mimori, Koshi ; Yamamoto, Ken ; Inoue, Hiroshi ; Imoto, Seiya ; Kawano, Shuichi ; Yamaguchi, Rui ; Sato, Tetsuya ; Toh, Hiroyuki ; Iinuma, Hisae ; Maeda, Toyoki ; Ishii, Hideshi ; Suzuki, Sadao ; Tokudome, Shinkan ; Watanabe, Masahiko ; Tanaka, Jun Ichi ; Kudo, Shin Ei ; Sugihara, Ken Ichi ; Hase, Kazuo ; Mochizuki, Hidetaka ; Kusunoki, Masato ; Yamada, Kazutaka ; Shimada, Yasuhiro ; Moriya, Yoshihiro ; Barnard, Graham F. ; Miyano, Satoru ; Mori, Masaki. / Increased risk for CRC in diabetic patients with the nonrisk allele of SNPs at 8q24. In: Annals of Surgical Oncology. 2012 ; Vol. 19, No. 9. pp. 2853-2858.
@article{080012d7ba8a4476bf1b261b106f594b,
title = "Increased risk for CRC in diabetic patients with the nonrisk allele of SNPs at 8q24",
abstract = "Background: Colorectal cancer (CRC) oncogenesis was considered to be determined by interactions between genetic and environmental factors. Specific interacting factors that influence CRC morbidity have yet to be fully investigated. Methods: A multi-institutional collaborative study with 1511 CRC patients and 2098 control subjects was used to compare the odds ratios for the occurrence of polymorphisms at 11 known single nucleotide polymorphisms (SNPs). TaqMan PCR and questionnaires were used to evaluate the effects of environmental exposures. Results: Variants of rs6983267 on 8q24 were the most significant markers of risk for CRC (odds ratio 1.16, 95{\%} confidence interval 1.06-1.27, P = 0.0015). Non-insulindependent diabetes mellitus (DM), a higher body mass index at age 20, and meat consumption were environmental risk factors, whereas a tuna-rich diet and vitamin intake were protective factors. The cohort of rs6983267 SNP major (T) allele at 8q24 and DM had a 1.66-fold higher risk ratio than the cohort of major allele patients without DM. Conclusions: We confirmed that interactions between the genetic background and environmental factors are associated with increased risk for CRC. There is a robust risk of the minor G allele at the 8q24 rs6983267 SNP; however, a major T allele SNP could more clearly reveal a correlation with CRC specifically when DM is present.",
author = "Shinya Ishimaru and Koshi Mimori and Ken Yamamoto and Hiroshi Inoue and Seiya Imoto and Shuichi Kawano and Rui Yamaguchi and Tetsuya Sato and Hiroyuki Toh and Hisae Iinuma and Toyoki Maeda and Hideshi Ishii and Sadao Suzuki and Shinkan Tokudome and Masahiko Watanabe and Tanaka, {Jun Ichi} and Kudo, {Shin Ei} and Sugihara, {Ken Ichi} and Kazuo Hase and Hidetaka Mochizuki and Masato Kusunoki and Kazutaka Yamada and Yasuhiro Shimada and Yoshihiro Moriya and Barnard, {Graham F.} and Satoru Miyano and Masaki Mori",
year = "2012",
month = "9",
day = "1",
doi = "10.1245/s10434-012-2278-6",
language = "English",
volume = "19",
pages = "2853--2858",
journal = "Annals of Surgical Oncology",
issn = "1068-9265",
publisher = "Springer New York",
number = "9",

}

TY - JOUR

T1 - Increased risk for CRC in diabetic patients with the nonrisk allele of SNPs at 8q24

AU - Ishimaru, Shinya

AU - Mimori, Koshi

AU - Yamamoto, Ken

AU - Inoue, Hiroshi

AU - Imoto, Seiya

AU - Kawano, Shuichi

AU - Yamaguchi, Rui

AU - Sato, Tetsuya

AU - Toh, Hiroyuki

AU - Iinuma, Hisae

AU - Maeda, Toyoki

AU - Ishii, Hideshi

AU - Suzuki, Sadao

AU - Tokudome, Shinkan

AU - Watanabe, Masahiko

AU - Tanaka, Jun Ichi

AU - Kudo, Shin Ei

AU - Sugihara, Ken Ichi

AU - Hase, Kazuo

AU - Mochizuki, Hidetaka

AU - Kusunoki, Masato

AU - Yamada, Kazutaka

AU - Shimada, Yasuhiro

AU - Moriya, Yoshihiro

AU - Barnard, Graham F.

AU - Miyano, Satoru

AU - Mori, Masaki

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Background: Colorectal cancer (CRC) oncogenesis was considered to be determined by interactions between genetic and environmental factors. Specific interacting factors that influence CRC morbidity have yet to be fully investigated. Methods: A multi-institutional collaborative study with 1511 CRC patients and 2098 control subjects was used to compare the odds ratios for the occurrence of polymorphisms at 11 known single nucleotide polymorphisms (SNPs). TaqMan PCR and questionnaires were used to evaluate the effects of environmental exposures. Results: Variants of rs6983267 on 8q24 were the most significant markers of risk for CRC (odds ratio 1.16, 95% confidence interval 1.06-1.27, P = 0.0015). Non-insulindependent diabetes mellitus (DM), a higher body mass index at age 20, and meat consumption were environmental risk factors, whereas a tuna-rich diet and vitamin intake were protective factors. The cohort of rs6983267 SNP major (T) allele at 8q24 and DM had a 1.66-fold higher risk ratio than the cohort of major allele patients without DM. Conclusions: We confirmed that interactions between the genetic background and environmental factors are associated with increased risk for CRC. There is a robust risk of the minor G allele at the 8q24 rs6983267 SNP; however, a major T allele SNP could more clearly reveal a correlation with CRC specifically when DM is present.

AB - Background: Colorectal cancer (CRC) oncogenesis was considered to be determined by interactions between genetic and environmental factors. Specific interacting factors that influence CRC morbidity have yet to be fully investigated. Methods: A multi-institutional collaborative study with 1511 CRC patients and 2098 control subjects was used to compare the odds ratios for the occurrence of polymorphisms at 11 known single nucleotide polymorphisms (SNPs). TaqMan PCR and questionnaires were used to evaluate the effects of environmental exposures. Results: Variants of rs6983267 on 8q24 were the most significant markers of risk for CRC (odds ratio 1.16, 95% confidence interval 1.06-1.27, P = 0.0015). Non-insulindependent diabetes mellitus (DM), a higher body mass index at age 20, and meat consumption were environmental risk factors, whereas a tuna-rich diet and vitamin intake were protective factors. The cohort of rs6983267 SNP major (T) allele at 8q24 and DM had a 1.66-fold higher risk ratio than the cohort of major allele patients without DM. Conclusions: We confirmed that interactions between the genetic background and environmental factors are associated with increased risk for CRC. There is a robust risk of the minor G allele at the 8q24 rs6983267 SNP; however, a major T allele SNP could more clearly reveal a correlation with CRC specifically when DM is present.

UR - http://www.scopus.com/inward/record.url?scp=84867400939&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867400939&partnerID=8YFLogxK

U2 - 10.1245/s10434-012-2278-6

DO - 10.1245/s10434-012-2278-6

M3 - Article

C2 - 22434246

AN - SCOPUS:84867400939

VL - 19

SP - 2853

EP - 2858

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

IS - 9

ER -