Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium

Michele L. Coté, Mei Liu, Stefano Bonassi, Monica Neri, Ann G. Schwartz, David C. Christiani, Margaret R. Spitz, Joshua E. Muscat, Gad Rennert, Katja K. Aben, Angeline S. Andrew, Vladimir Bencko, Heike Bickeböller, Paolo Boffetta, Paul Brennan, Hermann Brenner, Eric J. Duell, Eleonora Fabianova, John K. Field, Lenka ForetovaSøren Friis, Curtis C. Harris, Ivana Holcatova, Yun Chul Hong, Dolores Isla, Vladimir Janout, Lambertus A. Kiemeney, Chikako Kiyohara, Qing Lan, Philip Lazarus, Jolanta Lissowska, Loic Le Marchand, Dana Mates, Keitaro Matsuo, Jose I. Mayordomo, John R. McLaughlin, Hal Morgenstern, Heiko Müeller, Irene Orlow, Bernard J. Park, Mila Pinchev, Olaide Y. Raji, Hedy S. Rennert, Peter Rudnai, Adeline Seow, Isabelle Stucker, Neonila Szeszenia-Dabrowska, M. Dawn Teare, Anne Tjønnelan, Donatella Ugolini, Henricus F.M. Van Der Heijden, Erich Wichmann, John K. Wiencke, Penella J. Woll, Ping Yang, David Zaridze, Zuo Feng Zhang, Carol J. Etzel, Rayjean J. Hung

Research output: Contribution to journalArticle

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Abstract

Background and methods: Familial aggregation of lung cancer exists after accounting for cigarette smoking. However, the extent to which family history affects risk by smoking status, histology, relative type and ethnicity is not well described. This pooled analysis included 24 case-control studies in the International Lung Cancer Consortium. Each study collected age of onset/interview, gender, race/ethnicity, cigarette smoking, histology and first-degree family history of lung cancer. Data from 24,380 lung cancer cases and 23,305 healthy controls were analysed. Unconditional logistic regression models and generalised estimating equations were used to estimate odds ratios and 95% confidence intervals. Results: Individuals with a first-degree relative with lung cancer had a 1.51-fold increase in the risk of lung cancer, after adjustment for smoking and other potential confounders (95% CI: 1.39, 1.63). The association was strongest for those with a family history in a sibling, after adjustment (odds ratios (OR) = 1.82, 95% CI: 1.62, 2.05). No modifying effect by histologic type was found. Never smokers showed a lower association with positive familial history of lung cancer (OR = 1.25, 95% CI: 1.03, 1.52), slightly stronger for those with an affected sibling (OR = 1.44, 95% CI: 1.07, 1.93), after adjustment. Conclusions: The occurrence of lung cancer among never smokers and similar magnitudes of the effect of family history on lung cancer risk across histological types suggests familial aggregation of lung cancer is independent of those risks associated with cigarette smoking. While the role of genetic variation in the aetiology of lung cancer remains to be fully characterised, family history assessment is immediately available and those with a positive history represent a higher risk group.

Original languageEnglish
Pages (from-to)1957-1968
Number of pages12
JournalEuropean Journal of Cancer
Volume48
Issue number13
DOIs
Publication statusPublished - Sep 1 2012

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Lung Neoplasms
Smoking
Odds Ratio
Social Adjustment
Siblings
Histology
Logistic Models
Age of Onset
Case-Control Studies
History
Confidence Intervals
Interviews

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Increased risk of lung cancer in individuals with a family history of the disease : A pooled analysis from the International Lung Cancer Consortium. / Coté, Michele L.; Liu, Mei; Bonassi, Stefano; Neri, Monica; Schwartz, Ann G.; Christiani, David C.; Spitz, Margaret R.; Muscat, Joshua E.; Rennert, Gad; Aben, Katja K.; Andrew, Angeline S.; Bencko, Vladimir; Bickeböller, Heike; Boffetta, Paolo; Brennan, Paul; Brenner, Hermann; Duell, Eric J.; Fabianova, Eleonora; Field, John K.; Foretova, Lenka; Friis, Søren; Harris, Curtis C.; Holcatova, Ivana; Hong, Yun Chul; Isla, Dolores; Janout, Vladimir; Kiemeney, Lambertus A.; Kiyohara, Chikako; Lan, Qing; Lazarus, Philip; Lissowska, Jolanta; Le Marchand, Loic; Mates, Dana; Matsuo, Keitaro; Mayordomo, Jose I.; McLaughlin, John R.; Morgenstern, Hal; Müeller, Heiko; Orlow, Irene; Park, Bernard J.; Pinchev, Mila; Raji, Olaide Y.; Rennert, Hedy S.; Rudnai, Peter; Seow, Adeline; Stucker, Isabelle; Szeszenia-Dabrowska, Neonila; Dawn Teare, M.; Tjønnelan, Anne; Ugolini, Donatella; Van Der Heijden, Henricus F.M.; Wichmann, Erich; Wiencke, John K.; Woll, Penella J.; Yang, Ping; Zaridze, David; Zhang, Zuo Feng; Etzel, Carol J.; Hung, Rayjean J.

In: European Journal of Cancer, Vol. 48, No. 13, 01.09.2012, p. 1957-1968.

Research output: Contribution to journalArticle

Coté, ML, Liu, M, Bonassi, S, Neri, M, Schwartz, AG, Christiani, DC, Spitz, MR, Muscat, JE, Rennert, G, Aben, KK, Andrew, AS, Bencko, V, Bickeböller, H, Boffetta, P, Brennan, P, Brenner, H, Duell, EJ, Fabianova, E, Field, JK, Foretova, L, Friis, S, Harris, CC, Holcatova, I, Hong, YC, Isla, D, Janout, V, Kiemeney, LA, Kiyohara, C, Lan, Q, Lazarus, P, Lissowska, J, Le Marchand, L, Mates, D, Matsuo, K, Mayordomo, JI, McLaughlin, JR, Morgenstern, H, Müeller, H, Orlow, I, Park, BJ, Pinchev, M, Raji, OY, Rennert, HS, Rudnai, P, Seow, A, Stucker, I, Szeszenia-Dabrowska, N, Dawn Teare, M, Tjønnelan, A, Ugolini, D, Van Der Heijden, HFM, Wichmann, E, Wiencke, JK, Woll, PJ, Yang, P, Zaridze, D, Zhang, ZF, Etzel, CJ & Hung, RJ 2012, 'Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium', European Journal of Cancer, vol. 48, no. 13, pp. 1957-1968. https://doi.org/10.1016/j.ejca.2012.01.038
Coté, Michele L. ; Liu, Mei ; Bonassi, Stefano ; Neri, Monica ; Schwartz, Ann G. ; Christiani, David C. ; Spitz, Margaret R. ; Muscat, Joshua E. ; Rennert, Gad ; Aben, Katja K. ; Andrew, Angeline S. ; Bencko, Vladimir ; Bickeböller, Heike ; Boffetta, Paolo ; Brennan, Paul ; Brenner, Hermann ; Duell, Eric J. ; Fabianova, Eleonora ; Field, John K. ; Foretova, Lenka ; Friis, Søren ; Harris, Curtis C. ; Holcatova, Ivana ; Hong, Yun Chul ; Isla, Dolores ; Janout, Vladimir ; Kiemeney, Lambertus A. ; Kiyohara, Chikako ; Lan, Qing ; Lazarus, Philip ; Lissowska, Jolanta ; Le Marchand, Loic ; Mates, Dana ; Matsuo, Keitaro ; Mayordomo, Jose I. ; McLaughlin, John R. ; Morgenstern, Hal ; Müeller, Heiko ; Orlow, Irene ; Park, Bernard J. ; Pinchev, Mila ; Raji, Olaide Y. ; Rennert, Hedy S. ; Rudnai, Peter ; Seow, Adeline ; Stucker, Isabelle ; Szeszenia-Dabrowska, Neonila ; Dawn Teare, M. ; Tjønnelan, Anne ; Ugolini, Donatella ; Van Der Heijden, Henricus F.M. ; Wichmann, Erich ; Wiencke, John K. ; Woll, Penella J. ; Yang, Ping ; Zaridze, David ; Zhang, Zuo Feng ; Etzel, Carol J. ; Hung, Rayjean J. / Increased risk of lung cancer in individuals with a family history of the disease : A pooled analysis from the International Lung Cancer Consortium. In: European Journal of Cancer. 2012 ; Vol. 48, No. 13. pp. 1957-1968.
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title = "Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium",
abstract = "Background and methods: Familial aggregation of lung cancer exists after accounting for cigarette smoking. However, the extent to which family history affects risk by smoking status, histology, relative type and ethnicity is not well described. This pooled analysis included 24 case-control studies in the International Lung Cancer Consortium. Each study collected age of onset/interview, gender, race/ethnicity, cigarette smoking, histology and first-degree family history of lung cancer. Data from 24,380 lung cancer cases and 23,305 healthy controls were analysed. Unconditional logistic regression models and generalised estimating equations were used to estimate odds ratios and 95{\%} confidence intervals. Results: Individuals with a first-degree relative with lung cancer had a 1.51-fold increase in the risk of lung cancer, after adjustment for smoking and other potential confounders (95{\%} CI: 1.39, 1.63). The association was strongest for those with a family history in a sibling, after adjustment (odds ratios (OR) = 1.82, 95{\%} CI: 1.62, 2.05). No modifying effect by histologic type was found. Never smokers showed a lower association with positive familial history of lung cancer (OR = 1.25, 95{\%} CI: 1.03, 1.52), slightly stronger for those with an affected sibling (OR = 1.44, 95{\%} CI: 1.07, 1.93), after adjustment. Conclusions: The occurrence of lung cancer among never smokers and similar magnitudes of the effect of family history on lung cancer risk across histological types suggests familial aggregation of lung cancer is independent of those risks associated with cigarette smoking. While the role of genetic variation in the aetiology of lung cancer remains to be fully characterised, family history assessment is immediately available and those with a positive history represent a higher risk group.",
author = "Cot{\'e}, {Michele L.} and Mei Liu and Stefano Bonassi and Monica Neri and Schwartz, {Ann G.} and Christiani, {David C.} and Spitz, {Margaret R.} and Muscat, {Joshua E.} and Gad Rennert and Aben, {Katja K.} and Andrew, {Angeline S.} and Vladimir Bencko and Heike Bickeb{\"o}ller and Paolo Boffetta and Paul Brennan and Hermann Brenner and Duell, {Eric J.} and Eleonora Fabianova and Field, {John K.} and Lenka Foretova and S{\o}ren Friis and Harris, {Curtis C.} and Ivana Holcatova and Hong, {Yun Chul} and Dolores Isla and Vladimir Janout and Kiemeney, {Lambertus A.} and Chikako Kiyohara and Qing Lan and Philip Lazarus and Jolanta Lissowska and {Le Marchand}, Loic and Dana Mates and Keitaro Matsuo and Mayordomo, {Jose I.} and McLaughlin, {John R.} and Hal Morgenstern and Heiko M{\"u}eller and Irene Orlow and Park, {Bernard J.} and Mila Pinchev and Raji, {Olaide Y.} and Rennert, {Hedy S.} and Peter Rudnai and Adeline Seow and Isabelle Stucker and Neonila Szeszenia-Dabrowska and {Dawn Teare}, M. and Anne Tj{\o}nnelan and Donatella Ugolini and {Van Der Heijden}, {Henricus F.M.} and Erich Wichmann and Wiencke, {John K.} and Woll, {Penella J.} and Ping Yang and David Zaridze and Zhang, {Zuo Feng} and Etzel, {Carol J.} and Hung, {Rayjean J.}",
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TY - JOUR

T1 - Increased risk of lung cancer in individuals with a family history of the disease

T2 - A pooled analysis from the International Lung Cancer Consortium

AU - Coté, Michele L.

AU - Liu, Mei

AU - Bonassi, Stefano

AU - Neri, Monica

AU - Schwartz, Ann G.

AU - Christiani, David C.

AU - Spitz, Margaret R.

AU - Muscat, Joshua E.

AU - Rennert, Gad

AU - Aben, Katja K.

AU - Andrew, Angeline S.

AU - Bencko, Vladimir

AU - Bickeböller, Heike

AU - Boffetta, Paolo

AU - Brennan, Paul

AU - Brenner, Hermann

AU - Duell, Eric J.

AU - Fabianova, Eleonora

AU - Field, John K.

AU - Foretova, Lenka

AU - Friis, Søren

AU - Harris, Curtis C.

AU - Holcatova, Ivana

AU - Hong, Yun Chul

AU - Isla, Dolores

AU - Janout, Vladimir

AU - Kiemeney, Lambertus A.

AU - Kiyohara, Chikako

AU - Lan, Qing

AU - Lazarus, Philip

AU - Lissowska, Jolanta

AU - Le Marchand, Loic

AU - Mates, Dana

AU - Matsuo, Keitaro

AU - Mayordomo, Jose I.

AU - McLaughlin, John R.

AU - Morgenstern, Hal

AU - Müeller, Heiko

AU - Orlow, Irene

AU - Park, Bernard J.

AU - Pinchev, Mila

AU - Raji, Olaide Y.

AU - Rennert, Hedy S.

AU - Rudnai, Peter

AU - Seow, Adeline

AU - Stucker, Isabelle

AU - Szeszenia-Dabrowska, Neonila

AU - Dawn Teare, M.

AU - Tjønnelan, Anne

AU - Ugolini, Donatella

AU - Van Der Heijden, Henricus F.M.

AU - Wichmann, Erich

AU - Wiencke, John K.

AU - Woll, Penella J.

AU - Yang, Ping

AU - Zaridze, David

AU - Zhang, Zuo Feng

AU - Etzel, Carol J.

AU - Hung, Rayjean J.

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Background and methods: Familial aggregation of lung cancer exists after accounting for cigarette smoking. However, the extent to which family history affects risk by smoking status, histology, relative type and ethnicity is not well described. This pooled analysis included 24 case-control studies in the International Lung Cancer Consortium. Each study collected age of onset/interview, gender, race/ethnicity, cigarette smoking, histology and first-degree family history of lung cancer. Data from 24,380 lung cancer cases and 23,305 healthy controls were analysed. Unconditional logistic regression models and generalised estimating equations were used to estimate odds ratios and 95% confidence intervals. Results: Individuals with a first-degree relative with lung cancer had a 1.51-fold increase in the risk of lung cancer, after adjustment for smoking and other potential confounders (95% CI: 1.39, 1.63). The association was strongest for those with a family history in a sibling, after adjustment (odds ratios (OR) = 1.82, 95% CI: 1.62, 2.05). No modifying effect by histologic type was found. Never smokers showed a lower association with positive familial history of lung cancer (OR = 1.25, 95% CI: 1.03, 1.52), slightly stronger for those with an affected sibling (OR = 1.44, 95% CI: 1.07, 1.93), after adjustment. Conclusions: The occurrence of lung cancer among never smokers and similar magnitudes of the effect of family history on lung cancer risk across histological types suggests familial aggregation of lung cancer is independent of those risks associated with cigarette smoking. While the role of genetic variation in the aetiology of lung cancer remains to be fully characterised, family history assessment is immediately available and those with a positive history represent a higher risk group.

AB - Background and methods: Familial aggregation of lung cancer exists after accounting for cigarette smoking. However, the extent to which family history affects risk by smoking status, histology, relative type and ethnicity is not well described. This pooled analysis included 24 case-control studies in the International Lung Cancer Consortium. Each study collected age of onset/interview, gender, race/ethnicity, cigarette smoking, histology and first-degree family history of lung cancer. Data from 24,380 lung cancer cases and 23,305 healthy controls were analysed. Unconditional logistic regression models and generalised estimating equations were used to estimate odds ratios and 95% confidence intervals. Results: Individuals with a first-degree relative with lung cancer had a 1.51-fold increase in the risk of lung cancer, after adjustment for smoking and other potential confounders (95% CI: 1.39, 1.63). The association was strongest for those with a family history in a sibling, after adjustment (odds ratios (OR) = 1.82, 95% CI: 1.62, 2.05). No modifying effect by histologic type was found. Never smokers showed a lower association with positive familial history of lung cancer (OR = 1.25, 95% CI: 1.03, 1.52), slightly stronger for those with an affected sibling (OR = 1.44, 95% CI: 1.07, 1.93), after adjustment. Conclusions: The occurrence of lung cancer among never smokers and similar magnitudes of the effect of family history on lung cancer risk across histological types suggests familial aggregation of lung cancer is independent of those risks associated with cigarette smoking. While the role of genetic variation in the aetiology of lung cancer remains to be fully characterised, family history assessment is immediately available and those with a positive history represent a higher risk group.

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U2 - 10.1016/j.ejca.2012.01.038

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VL - 48

SP - 1957

EP - 1968

JO - European Journal of Cancer and Clinical Oncology

JF - European Journal of Cancer and Clinical Oncology

SN - 0959-8049

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