TY - JOUR
T1 - Increased serum levels of interferon-γ-inducible protein 10 and monokine induced by gamma interferon in patients with haemophagocytic lymphohistiocytosis
AU - Takada, Hidetoshi
AU - Takahata, Y.
AU - Nomura, A.
AU - Ohga, S.
AU - Mizuno, Y.
AU - Hara, T.
PY - 2003/9/1
Y1 - 2003/9/1
N2 - We measured serum interferon-gamma-inducible protein 10 (IP-10) and monokine induced by gamma interferon (MIG) levels to investigate the role of these molecules in the pathophysiology of haemophagocytic lymphohistiocytosis (HLH). Serum IP-10 and MIG levels were significantly increased in patients with active HLH compared with those of healthy controls. Serum MIG levels decreased gradually during the course of disease in a patient who recovered without therapy. On the other hand, rapid reduction of MIG and IP-10 levels was observed after chemotherapy in a patient with severe HLH. IP-10 and MIG mRNA expression was enhanced in liver and spleen, and IP-10 mRNA expression was enhanced in bone marrow in the patients, suggesting activated macrophages that infiltrated in these organs as one of the main producers of these cytokines. Serum IP-10 and MIG levels showed a significant correlation with serum IFN-γ levels. In addition, these chemokines had a significant correlation with fever and serum LDH levels, which are clinical indicators of disease activity of HLH. These results suggest that IP-10 and MIG which are produced by activated macrophages by the stimulation of IFN-γ, play an important role in the pathophysiology of HLH, by recruitment of activated Th1 cells into the tissues or organs.
AB - We measured serum interferon-gamma-inducible protein 10 (IP-10) and monokine induced by gamma interferon (MIG) levels to investigate the role of these molecules in the pathophysiology of haemophagocytic lymphohistiocytosis (HLH). Serum IP-10 and MIG levels were significantly increased in patients with active HLH compared with those of healthy controls. Serum MIG levels decreased gradually during the course of disease in a patient who recovered without therapy. On the other hand, rapid reduction of MIG and IP-10 levels was observed after chemotherapy in a patient with severe HLH. IP-10 and MIG mRNA expression was enhanced in liver and spleen, and IP-10 mRNA expression was enhanced in bone marrow in the patients, suggesting activated macrophages that infiltrated in these organs as one of the main producers of these cytokines. Serum IP-10 and MIG levels showed a significant correlation with serum IFN-γ levels. In addition, these chemokines had a significant correlation with fever and serum LDH levels, which are clinical indicators of disease activity of HLH. These results suggest that IP-10 and MIG which are produced by activated macrophages by the stimulation of IFN-γ, play an important role in the pathophysiology of HLH, by recruitment of activated Th1 cells into the tissues or organs.
UR - http://www.scopus.com/inward/record.url?scp=0041825409&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0041825409&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2249.2003.02237.x
DO - 10.1046/j.1365-2249.2003.02237.x
M3 - Article
C2 - 12930373
AN - SCOPUS:0041825409
SN - 0009-9104
VL - 133
SP - 448
EP - 453
JO - Clinical and Experimental Immunology
JF - Clinical and Experimental Immunology
IS - 3
ER -