Increased tyrosine in the brain and serum of mice by orally administering dipeptide SY

Kayoko Esaki; Taketo Ohmori; Motohiro Maebuchi; Toshihiro Nakamori; Toshihisa Ohshima; Shigeki Furuya

doi:10.1271/bbb.120747

Increased tyrosine in the brain and serum of mice by orally administering dipeptide SY

Kayoko Esaki, Taketo Ohmori, Motohiro Maebuchi, Toshihiro Nakamori, Toshihisa Ohshima, Shigeki Furuya

Systems Biology

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7 Citations (Scopus)

Abstract

We examined the effect of orally administering L-Ser-L-Tyr (SY) dipeptide on the brain of a serine deficiency disease model mouse to attain the efficient delivery of L-Tyr and L-Ser into the mouse brain. Oral SY administration increased the L-Tyr level more efficiently than L-Tyr administration with the same intake dose, but did not significantly affect the L-Ser level when compared with L-Ser administration.

Original language	English
Pages (from-to)	847-849
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	77
Issue number	4
DOIs	https://doi.org/10.1271/bbb.120747
Publication status	Published - 2013

All Science Journal Classification (ASJC) codes

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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abstract = "We examined the effect of orally administering L-Ser-L-Tyr (SY) dipeptide on the brain of a serine deficiency disease model mouse to attain the efficient delivery of L-Tyr and L-Ser into the mouse brain. Oral SY administration increased the L-Tyr level more efficiently than L-Tyr administration with the same intake dose, but did not significantly affect the L-Ser level when compared with L-Ser administration.",

author = "Kayoko Esaki and Taketo Ohmori and Motohiro Maebuchi and Toshihiro Nakamori and Toshihisa Ohshima and Shigeki Furuya",

note = "Funding Information: This study was supported in part by grants from the Fuji Foundation for Protein Research to S.F., and from the Bio-oriented Technology Research Advancement Institution (BRAIN) to T.O.",

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T1 - Increased tyrosine in the brain and serum of mice by orally administering dipeptide SY

AU - Esaki, Kayoko

AU - Ohmori, Taketo

AU - Maebuchi, Motohiro

AU - Nakamori, Toshihiro

AU - Ohshima, Toshihisa

AU - Furuya, Shigeki

N1 - Funding Information: This study was supported in part by grants from the Fuji Foundation for Protein Research to S.F., and from the Bio-oriented Technology Research Advancement Institution (BRAIN) to T.O.

PY - 2013

Y1 - 2013

N2 - We examined the effect of orally administering L-Ser-L-Tyr (SY) dipeptide on the brain of a serine deficiency disease model mouse to attain the efficient delivery of L-Tyr and L-Ser into the mouse brain. Oral SY administration increased the L-Tyr level more efficiently than L-Tyr administration with the same intake dose, but did not significantly affect the L-Ser level when compared with L-Ser administration.

AB - We examined the effect of orally administering L-Ser-L-Tyr (SY) dipeptide on the brain of a serine deficiency disease model mouse to attain the efficient delivery of L-Tyr and L-Ser into the mouse brain. Oral SY administration increased the L-Tyr level more efficiently than L-Tyr administration with the same intake dose, but did not significantly affect the L-Ser level when compared with L-Ser administration.

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SN - 0916-8451

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ER -

Increased tyrosine in the brain and serum of mice by orally administering dipeptide SY

Abstract

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