Increased tyrosine in the brain and serum of mice by orally administering dipeptide SY

Kayoko Esaki; Taketo Ohmori; Motohiro Maebuchi; Toshihiro Nakamori; Toshihisa Ohshima; Shigeki Furuya

doi:10.1271/bbb.120747

Increased tyrosine in the brain and serum of mice by orally administering dipeptide SY

Kayoko Esaki, Taketo Ohmori, Motohiro Maebuchi, Toshihiro Nakamori, Toshihisa Ohshima, Shigeki Furuya

Systems Biology

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

We examined the effect of orally administering L-Ser-L-Tyr (SY) dipeptide on the brain of a serine deficiency disease model mouse to attain the efficient delivery of L-Tyr and L-Ser into the mouse brain. Oral SY administration increased the L-Tyr level more efficiently than L-Tyr administration with the same intake dose, but did not significantly affect the L-Ser level when compared with L-Ser administration.

Original language	English
Pages (from-to)	847-849
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	77
Issue number	4
DOIs	https://doi.org/10.1271/bbb.120747
Publication status	Published - 2013

All Science Journal Classification (ASJC) codes

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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abstract = "We examined the effect of orally administering L-Ser-L-Tyr (SY) dipeptide on the brain of a serine deficiency disease model mouse to attain the efficient delivery of L-Tyr and L-Ser into the mouse brain. Oral SY administration increased the L-Tyr level more efficiently than L-Tyr administration with the same intake dose, but did not significantly affect the L-Ser level when compared with L-Ser administration.",

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AU - Ohmori, Taketo

AU - Maebuchi, Motohiro

AU - Nakamori, Toshihiro

AU - Ohshima, Toshihisa

AU - Furuya, Shigeki

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