Increased variation in ADH enzyme activity in Drosophila mutation-accumulation experiment is not due to transposable elements at the Adh structural gene

C. F. Aquadro, H. Tachida, C. H. Langley, K. Harada, T. Mukai

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We present here a molecular analysis of the region surrounding the structural gene encoding alcohol dehydrogenase (Adh) in 47 lines of Drosophila melanogaster that have each accumulated mutations for 300 generations. While these lines show a significant increase in variation of alcohol dehydrogenase enzyme activity compared to control lines, we found no restriction map variation in a 13-kb region including the complete Adh structural gene and roughly 5 kb of both 5' and 3' sequences. Thus, the rapid accumulation of ADH activity variation after 28,200 allele generations does not appear to have been due to the mobilization of transposable elements into or out of the Adh structural gene region.

Original languageEnglish
Pages (from-to)915-919
Number of pages5
JournalGenetics
Volume126
Issue number4
Publication statusPublished - Dec 1 1990

All Science Journal Classification (ASJC) codes

  • Genetics

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