Increases in helper induced T cells and activated T cells in HTLV‐I–associated myelopathy

Yasuto Itoyama, Jun‐ichi ‐i Kira, Naoki Fujii, Ikuo Goto, Naoki Yamamoto

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)

Abstract

Using two‐color flow cytometric analysis, we studied peripheral blood lymphocyte subsets in 15 patients with human T‐cell lymphotropic virus type I–associated myelopathy. The percentage of CD 4+4B4+ cells (helper inducer T cell) was significantly increased in the patients with the myelopathy, compared with 16 healthy control subjects who were seronegative for human T‐cell lymphotropic virus type I. However, there was no difference in the percentage of CD4+2H4+ cells (suppressor inducer T cell) between the two groups. The ratio of CD4+4B4+ cells to CD4+ cells and CD4+4B4+ to CD4+ 2H4+ cells was also elevated in these patients. The percentage of CD4+DR+ cells and CD8+DR+ cells, both of which are phenotypically activated T cells, and the ratio of CD4+DR+ cells to CD4+ cells and of CD8+DR+ cells to CD8+ cells are also increased in the patients, compared with the control subjects. The percentage of Cd4+4B4+ cells showed positive correlations with values of spontaneous proliferation of peripheral blood lymphocytes and serum IgG level in patients with the myhelopathy.

Original languageEnglish
Pages (from-to)257-262
Number of pages6
JournalAnnals of Neurology
Volume26
Issue number2
DOIs
Publication statusPublished - Aug 1989

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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