### Abstract

Using the estimates of additive genetic variance and dominance variance as well as the regression coefficient of heterozygotes on the sums of the component homozygotes (βY-x) and the inverse of the regression coefficient of the sum of the two homozygotes on their heterozygotes (l/fβY-x} with respect to viability estimated by the Cy method, it was tested whether or not frequency-dependent selection is a general rule with respect to viability polygenes. Two types of frequency-dependent selection models were considered: (1) gene frequency-dependent model and (2) zygotic frequency-dependent model. The βy.x and 1/βx-y values predicted on the basis of the frequency-dependent selection models and the ratio of the dominance variance to the additive variance are inconsistent with the actual estimates of these parameters for the Florida, Ishigaki-jima (Japan), Raleigh (N.C.) and Aomori (Japan) populations. The same oonclusion was obtained for newly arisen polygenic viability mutations. Thus, it is speculated that frequency dependent selection is not a general rule for viability polygenes as well as polymorphic isozyme genes.

Original language | English |
---|---|

Pages (from-to) | 297-314 |

Number of pages | 18 |

Journal | The Japanese Journal of Genetics |

Volume | 58 |

Issue number | 4 |

DOIs | |

Publication status | Published - Jan 1 1983 |

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### All Science Journal Classification (ASJC) codes

- Genetics

### Cite this

*The Japanese Journal of Genetics*,

*58*(4), 297-314. https://doi.org/10.1266/jjg.58.297

**Indirect negative evidence for frequency-dependent selection with respect to viability in Drosophila melanogaster.** / Mukai, Terumi; Kusakabe, Shin ichi; Tachida, Hidenori.

Research output: Contribution to journal › Article

*The Japanese Journal of Genetics*, vol. 58, no. 4, pp. 297-314. https://doi.org/10.1266/jjg.58.297

}

TY - JOUR

T1 - Indirect negative evidence for frequency-dependent selection with respect to viability in Drosophila melanogaster

AU - Mukai, Terumi

AU - Kusakabe, Shin ichi

AU - Tachida, Hidenori

PY - 1983/1/1

Y1 - 1983/1/1

N2 - Using the estimates of additive genetic variance and dominance variance as well as the regression coefficient of heterozygotes on the sums of the component homozygotes (βY-x) and the inverse of the regression coefficient of the sum of the two homozygotes on their heterozygotes (l/fβY-x} with respect to viability estimated by the Cy method, it was tested whether or not frequency-dependent selection is a general rule with respect to viability polygenes. Two types of frequency-dependent selection models were considered: (1) gene frequency-dependent model and (2) zygotic frequency-dependent model. The βy.x and 1/βx-y values predicted on the basis of the frequency-dependent selection models and the ratio of the dominance variance to the additive variance are inconsistent with the actual estimates of these parameters for the Florida, Ishigaki-jima (Japan), Raleigh (N.C.) and Aomori (Japan) populations. The same oonclusion was obtained for newly arisen polygenic viability mutations. Thus, it is speculated that frequency dependent selection is not a general rule for viability polygenes as well as polymorphic isozyme genes.

AB - Using the estimates of additive genetic variance and dominance variance as well as the regression coefficient of heterozygotes on the sums of the component homozygotes (βY-x) and the inverse of the regression coefficient of the sum of the two homozygotes on their heterozygotes (l/fβY-x} with respect to viability estimated by the Cy method, it was tested whether or not frequency-dependent selection is a general rule with respect to viability polygenes. Two types of frequency-dependent selection models were considered: (1) gene frequency-dependent model and (2) zygotic frequency-dependent model. The βy.x and 1/βx-y values predicted on the basis of the frequency-dependent selection models and the ratio of the dominance variance to the additive variance are inconsistent with the actual estimates of these parameters for the Florida, Ishigaki-jima (Japan), Raleigh (N.C.) and Aomori (Japan) populations. The same oonclusion was obtained for newly arisen polygenic viability mutations. Thus, it is speculated that frequency dependent selection is not a general rule for viability polygenes as well as polymorphic isozyme genes.

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U2 - 10.1266/jjg.58.297

DO - 10.1266/jjg.58.297

M3 - Article

VL - 58

SP - 297

EP - 314

JO - Genes and Genetic Systems

JF - Genes and Genetic Systems

SN - 1341-7568

IS - 4

ER -