Individual and group housing in N-type Ca2+ channel α1B subunit-deficient mice differently affect motor activity

Eiki Takahashi, Takeshi Nagasu

Research output: Contribution to journalArticlepeer-review

Abstract

N-type Ca2+ channel α1B-deficient mice have increased activity (ambulation, repetitive behavior, and rearing combined), suggesting contribution by the N-type Ca2+ channel, localized in the plasma membrane and essential for neurotransmitter release, on motor activity. We evaluated the effect of a 6-wk postweaning period of either individual or group housing on the activity displayed in a novel environment with or without previous habituation. Without habituation, male homozygous α1B- deficient mice showed significantly higher activity than wild-type controls, with no influence of the housing condition. When habituated, hyperactivity was seen in individually housed but not group-housed homozygous α 1B-deficient mice. The results indicate that controlling for housing condition can be important when phenotypically analyzing mutant mice.

Original languageEnglish
Pages (from-to)44-47
Number of pages4
JournalJournal of the American Association for Laboratory Animal Science
Volume45
Issue number5
Publication statusPublished - Sep 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology

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