Indole-3-carbaldehyde: A tyrosinase inhibitor from fungus YL185

Kuniyoshi Shimizu, Xinglian Geng, Mika Hashiguchi, Hiroto Suhara, Syoko Fukunaga, Seiji Yasutake, Ryuichiro Kondo, Mototake Tsutsui, Ikuo Sato

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8 Citations (Scopus)

Abstract

Indole-3-carbaldehyde (1) was isolated as a tyrosinase inhibitor from the ethyl acetate-soluble fraction of extracellular fluids of unknown fungus YL185. The partial sequencing data of 18S ribosomal DNA (18S rDNA) indicate that this isolate belongs to the family Polyporaceae or Corticiaceae sensu lato. Indole-3-carbaldehyde inhibited the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) by mushroom tyrosinase with a 50% inhibitory concentration (IC 50) of 1.3 mM and showed inhibitory activity on melanin production in B16 melanoma cells. The aldehyde group of 1 plays an important role in eliciting tyrosinase inhibitory activity.

Original languageEnglish
Pages (from-to)349-354
Number of pages6
JournalJournal of Wood Science
Volume49
Issue number4
DOIs
Publication statusPublished - Oct 31 2003

All Science Journal Classification (ASJC) codes

  • Biomaterials

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    Shimizu, K., Geng, X., Hashiguchi, M., Suhara, H., Fukunaga, S., Yasutake, S., Kondo, R., Tsutsui, M., & Sato, I. (2003). Indole-3-carbaldehyde: A tyrosinase inhibitor from fungus YL185. Journal of Wood Science, 49(4), 349-354. https://doi.org/10.1007/s10086-002-0484-8