Indonesian children fecal microbiome from birth until weaning was different from microbiomes of their mothers

Wei Wei Thwe Khine, Endang Sutriswati Rahayu, Ting Yi See, Sherwin Kuah, Seppo Salminen, Jiro Nakayama, Yuan Kun Lee

Research output: Contribution to journalArticle

Abstract

Gastrointestinal (GI) microbiota play an important role in human health and wellbeing and the first wave of gut microbes arrives mostly through vertical transmission from mother to child. This study has undertaken to understand the microbiota profile of healthy Southeast Asian mother-infant pairs. Here, we examined the fecal, vaginal and breast milk microbiota of Indonesian mothers and the fecal microbiota of their children from less than 1 month to 48 months old. To determine the immune status of children and the effect of diet at different ages, we examined the level of cytokines, bile acids in the fecal water and weaning food frequency. The fecal microbiota of the children before weaning contained mainly Bacteroides and Bifidobacterium, which presented at low abundance in the samples of mothers. After weaning, the fecal microbiome of children was mainly of the Prevotella type, with decreasing levels of Bifidobacterium, thus becoming more like the fecal microbiome of the mother. The abundance of infant fecal commensals generally correlated inversely with potential pathogens before weaning. The fecal Bifidobacterium in children correlated inversely with the consumption of complex carbohydrates and fruits after weaning. The specific cytokines related to the proliferation and maturation of immunity were found to increase after weaning. A decreasing level of primary bile acids and an increase of secondary bile acids were observed after weaning. This study highlights the change in the GI microbiota of infants to adult-type microbiota after weaning and identifies diet as a major contributing factor.

Original languageEnglish
Article number1761240
JournalGut Microbes
Volume12
Issue number1
DOIs
Publication statusAccepted/In press - 2020

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Gastroenterology
  • Microbiology (medical)
  • Infectious Diseases

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    Khine, W. W. T., Rahayu, E. S., See, T. Y., Kuah, S., Salminen, S., Nakayama, J., & Lee, Y. K. (Accepted/In press). Indonesian children fecal microbiome from birth until weaning was different from microbiomes of their mothers. Gut Microbes, 12(1), [1761240]. https://doi.org/10.1080/19490976.2020.1761240