Induction of δ-Glutamyltrans-Peptidase Positive Foci in Rat Liver by Deoxycholic Acid

Hitoshi Ura; Yoshihiko Yokose; Kazuhiro Mizumoto; Akira Nakajima; Kazuhiko Yamamoto; Ayumi Denda; Yoichi Konishi

Induction of δ-Glutamyltrans-Peptidase Positive Foci in Rat Liver by Deoxycholic Acid

Hitoshi Ura, Yoshihiko Yokose, Kazuhiro Mizumoto, Akira Nakajima, Kazuhiko Yamamoto, Ayumi Denda, Yoichi Konishi

Research output: Contribution to journal › Article › peer-review

Abstract

Initiating activities of the secondary bile acids, deoxycholic acid (DCA) and lithocholic acid (LCA), were examined in terms of the induction of 7-glutamyltranspeptidase(GGT)positive foci in rat liver. A rapid induction model of enzyme-altered foci was utilized. GGT positive foci were clearly induced by DCA ranging from 0.05% to 0.5% in the diet. In contrast, the induction of GGT positive foci by LCA was less pronounced and was not dosedependent. These results suggest that DCA possesses initiating activity.

Original language	English
Pages (from-to)	216-218
Number of pages	3
Journal	Japanese Journal of Cancer Research GANN
Volume	78
Issue number	3
Publication status	Published - Jan 1 1987
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Induction of δ-Glutamyltrans-Peptidase Positive Foci in Rat Liver by Deoxycholic Acid",

abstract = "Initiating activities of the secondary bile acids, deoxycholic acid (DCA) and lithocholic acid (LCA), were examined in terms of the induction of 7-glutamyltranspeptidase(GGT)positive foci in rat liver. A rapid induction model of enzyme-altered foci was utilized. GGT positive foci were clearly induced by DCA ranging from 0.05% to 0.5% in the diet. In contrast, the induction of GGT positive foci by LCA was less pronounced and was not dosedependent. These results suggest that DCA possesses initiating activity.",

author = "Hitoshi Ura and Yoshihiko Yokose and Kazuhiro Mizumoto and Akira Nakajima and Kazuhiko Yamamoto and Ayumi Denda and Yoichi Konishi",

year = "1987",

month = jan,

day = "1",

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volume = "78",

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journal = "Cancer Science",

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T1 - Induction of δ-Glutamyltrans-Peptidase Positive Foci in Rat Liver by Deoxycholic Acid

AU - Ura, Hitoshi

AU - Yokose, Yoshihiko

AU - Mizumoto, Kazuhiro

AU - Nakajima, Akira

AU - Yamamoto, Kazuhiko

AU - Denda, Ayumi

AU - Konishi, Yoichi

PY - 1987/1/1

Y1 - 1987/1/1

N2 - Initiating activities of the secondary bile acids, deoxycholic acid (DCA) and lithocholic acid (LCA), were examined in terms of the induction of 7-glutamyltranspeptidase(GGT)positive foci in rat liver. A rapid induction model of enzyme-altered foci was utilized. GGT positive foci were clearly induced by DCA ranging from 0.05% to 0.5% in the diet. In contrast, the induction of GGT positive foci by LCA was less pronounced and was not dosedependent. These results suggest that DCA possesses initiating activity.

AB - Initiating activities of the secondary bile acids, deoxycholic acid (DCA) and lithocholic acid (LCA), were examined in terms of the induction of 7-glutamyltranspeptidase(GGT)positive foci in rat liver. A rapid induction model of enzyme-altered foci was utilized. GGT positive foci were clearly induced by DCA ranging from 0.05% to 0.5% in the diet. In contrast, the induction of GGT positive foci by LCA was less pronounced and was not dosedependent. These results suggest that DCA possesses initiating activity.

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JO - Cancer Science

JF - Cancer Science

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ER -

Induction of δ-Glutamyltrans-Peptidase Positive Foci in Rat Liver by Deoxycholic Acid

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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