Induction of δ-Glutamyltrans-Peptidase Positive Foci in Rat Liver by Deoxycholic Acid

Hitoshi Ura, Yoshihiko Yokose, Kazuhiro Mizumoto, Akira Nakajima, Kazuhiko Yamamoto, Ayumi Denda, Yoichi Konishi

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Abstract

Initiating activities of the secondary bile acids, deoxycholic acid (DCA) and lithocholic acid (LCA), were examined in terms of the induction of 7-glutamyltranspeptidase(GGT)positive foci in rat liver. A rapid induction model of enzyme-altered foci was utilized. GGT positive foci were clearly induced by DCA ranging from 0.05% to 0.5% in the diet. In contrast, the induction of GGT positive foci by LCA was less pronounced and was not dosedependent. These results suggest that DCA possesses initiating activity.

Original languageEnglish
Pages (from-to)216-218
Number of pages3
JournalJapanese Journal of Cancer Research GANN
Volume78
Issue number3
Publication statusPublished - Jan 1 1987
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Ura, H., Yokose, Y., Mizumoto, K., Nakajima, A., Yamamoto, K., Denda, A., & Konishi, Y. (1987). Induction of δ-Glutamyltrans-Peptidase Positive Foci in Rat Liver by Deoxycholic Acid. Japanese Journal of Cancer Research GANN, 78(3), 216-218.