Induction of a cytosolic 54 kDa protein in rat liver that is highly homologous to selenium-binding protein

Takumi Ishida, Kenji Tasaki, Ayako Fukuda, Yuji Ishii, Kazuta Oguri

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We have previously shown that a 54 kDa protein in rat liver is highly homologous to selenium-binding protein (SeBP) or acetaminophen-binding protein (APBP) in mice and is highly inducible by treatment with 3,3',4,4',5-pentachlorobiphenyl or 3-methylcholanthrene. In this study, we examine the effect of six typical inducers, 3-methylcholanthrene (MC), isosafrole (ISO), phenobarbital (PB), dexamethasone (DEX), clofibrate (CLO), pyrazole (PYR) and butylated hydroxytoluene (BHT), on the expression level of this 54 kDa protein. Male Wistar rats were given each inducer following a predetermined schedule. Among these inducers, the 54 kDa protein was inducible by MC and BHT. The response to MC and BHT was compared with that of NAD(P)H: quinone oxidoreductase and ethoxyresorufin O-deethylase activities. The induction mechanisms and physiological role of the 54 kDa protein are discussed in the light of our results. Copyright (C) 1998 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)249-255
Number of pages7
JournalEnvironmental Toxicology and Pharmacology
Volume6
Issue number4
DOIs
Publication statusPublished - Dec 1 1998

Fingerprint

Selenium-Binding Proteins
Methylcholanthrene
Liver
Butylated Hydroxytoluene
Rats
3,4,5,3',4'-pentachlorobiphenyl
Proteins
Clofibrate
Cytochrome P-450 CYP1A1
Phenobarbital
Acetaminophen
NAD
Dexamethasone
Wistar Rats
Appointments and Schedules
Carrier Proteins
Oxidoreductases

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

Cite this

Induction of a cytosolic 54 kDa protein in rat liver that is highly homologous to selenium-binding protein. / Ishida, Takumi; Tasaki, Kenji; Fukuda, Ayako; Ishii, Yuji; Oguri, Kazuta.

In: Environmental Toxicology and Pharmacology, Vol. 6, No. 4, 01.12.1998, p. 249-255.

Research output: Contribution to journalArticle

Ishida, Takumi ; Tasaki, Kenji ; Fukuda, Ayako ; Ishii, Yuji ; Oguri, Kazuta. / Induction of a cytosolic 54 kDa protein in rat liver that is highly homologous to selenium-binding protein. In: Environmental Toxicology and Pharmacology. 1998 ; Vol. 6, No. 4. pp. 249-255.
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