Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments

Bruce T. Hope, Heather E. Nye, Max B. Kelz, David W. Self, Michael J. Iadarola, Yusaku Nakabeppu, Ronald S. Duman, Eric J. Nestler

Research output: Contribution to journalArticle

464 Citations (Scopus)

Abstract

Following chronic cocaine treatment, we have found a long-lasting increase in AP-1 binding in the rat nucleus accumbens and striatum, two important targets of the behavioral effects of cocaine. This increase develops gradually over several days and remains at 50% of maximal levels 7 days after the last cocaine exposure. Supershift experiments, along with one- and two-dimensional Western blots, indicate that this chronic AP-1 complex contains at least four Fos-related antigens (FRAs), some of which display ΔFosB-like immunoreactivity, that are induced selectively by chronic, but not acute, cocaine treatment. The same chronic FRAs were also induced by several different types of chronic treatments in a region-specific manner in the brain. Thus, the chronic FBAs and associated chronic AP-1 complex could mediate some of the long-term changes in gene expression unique to the chronic-treated state as opposed to the acute-treated and normal states.

Original languageEnglish
Pages (from-to)1235-1244
Number of pages10
JournalNeuron
Volume13
Issue number5
DOIs
Publication statusPublished - Nov 1994

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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