Induction of ADCC by a folic acid-mAb conjugate prepared by tryptophan-selective reaction toward folate-receptor-positive cancer cells

Hiroshi Tagawa, Katsuya Maruyama, Koichi Sasaki, Natsuki Konoue, Akihiro Kishimura, Motomu Kanai, Takeshi Mori, Kounosuke Oisaki, Yoshiki Katayama

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We developed conjugates between monoclonal antibody (mAb) and folic acid (FA) by using a tryptophan (Trp)-selective reaction, which yields relatively homogenous products compared to conventional methods. The obtained mAb-FA conjugates showed significant cellular cytotoxicity toward folate receptor-expressing cancer cells, demonstrating that the conjugates retained the Fc region's original function.

Original languageEnglish
Pages (from-to)16727-16731
Number of pages5
JournalRSC Advances
Volume10
Issue number28
DOIs
Publication statusPublished - Apr 29 2020

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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