Induction of bilirubin UDP-glucuronyltransferase and CYP4A1 P450 by co-planar PCBs: Different responsiveness of guinea pigs and rats

Y. Koga, M. Tsuda, N. Ariyoshi, Y. Ishii, H. Yamada, K. Oguri, Y. Funae, H. Yoshimura

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10 Citations (Scopus)

Abstract

Induction of hepatic microsomal bilirubin UDP_glucuronyltransferase and CYP4A1 P450 by 3,4,3′,4′-tetrachlorobiphenyl (TCB) and 3,4,5,3′,4′-pentachlorobiphenyl (PenCB) was studied in guinea pigs and rats. Both enzyme activities in guinea pigs were increased 4-fold or more over the control by PenCB treatment, while by treatment with a less toxic congener, TCB, these were increased to a lesser extent. On the contrary, the rat enzymes were significantly decreased by treatment with these co-planar polychlorinated biphenyls. These results suggest that the alterations of both bilirubin UDP-glucuronyltransferase and CYP4A P450 are the characteristic indices for the toxicites of polychlorinated hydrocarbons.

Original languageEnglish
Pages (from-to)639-645
Number of pages7
JournalChemosphere
Volume28
Issue number3
DOIs
Publication statusPublished - Feb 1994

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

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