Induction of Cervical Intraepithelial Neoplasia in BALB/c Mice by UV‐Inactivated Herpes Simplex Virus Type 2

Yoshinobu Hayashi, Nobuo Okabe, Ryoichi Mori, Tsunehisa Kaku, Shirou Mohri, Tsuyoshi Iwasaka, Hajime Sugimori

Research output: Contribution to journalArticlepeer-review

Abstract

The present study was undertaken to investigate the oncogenic potential of herpes simplex virus type 2 (HSV‐2) in the mouse cervix and the effect of tetradecanoyl‐phorbol‐acetate (TPA) on the development of HSV‐2‐induced cervical lesion. Cotton tampons saturated with ultraviolet‐inactivated HSV‐2 were inserted into the vaginas of BALB/c mice twice a week. Histological examination performed at the 48th week revealed cervical intraepithelial neoplasia in a HSV‐2‐exposed mouse and a HSV‐2 plus TPA‐exposed mouse but not in control mice. Although premalignant lesions were induced in the mouse uterine cervices by HSV‐2, there was no evidence of malignancy. These results suggest that HSV‐2 functions as an initiator in the multistep process of cervical carcinogenesis.

Original languageEnglish
Pages (from-to)379-382
Number of pages4
JournalAsia‐Oceania Journal of Obstetrics and Gynaecology
Volume14
Issue number3
DOIs
Publication statusPublished - Sep 1988

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

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