The present study was undertaken to investigate the oncogenic potential of herpes simplex virus type 2 (HSV‐2) in the mouse cervix and the effect of tetradecanoyl‐phorbol‐acetate (TPA) on the development of HSV‐2‐induced cervical lesion. Cotton tampons saturated with ultraviolet‐inactivated HSV‐2 were inserted into the vaginas of BALB/c mice twice a week. Histological examination performed at the 48th week revealed cervical intraepithelial neoplasia in a HSV‐2‐exposed mouse and a HSV‐2 plus TPA‐exposed mouse but not in control mice. Although premalignant lesions were induced in the mouse uterine cervices by HSV‐2, there was no evidence of malignancy. These results suggest that HSV‐2 functions as an initiator in the multistep process of cervical carcinogenesis.
|Number of pages||4|
|Journal||Asia‐Oceania Journal of Obstetrics and Gynaecology|
|Publication status||Published - Sep 1988|
All Science Journal Classification (ASJC) codes
- Obstetrics and Gynaecology