Induction of Cervical Intraepithelial Neoplasia in BALB/c Mice by UV‐Inactivated Herpes Simplex Virus Type 2

Yoshinobu Hayashi; Nobuo Okabe; Ryoichi Mori; Tsunehisa Kaku; Shirou Mohri; Tsuyoshi Iwasaka; Hajime Sugimori

doi:10.1111/j.1447-0756.1988.tb00120.x

Induction of Cervical Intraepithelial Neoplasia in BALB/c Mice by UV‐Inactivated Herpes Simplex Virus Type 2

Yoshinobu Hayashi, Nobuo Okabe, Ryoichi Mori, Tsunehisa Kaku, Shirou Mohri, Tsuyoshi Iwasaka, Hajime Sugimori

Division of Nursing

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Abstract

The present study was undertaken to investigate the oncogenic potential of herpes simplex virus type 2 (HSV‐2) in the mouse cervix and the effect of tetradecanoyl‐phorbol‐acetate (TPA) on the development of HSV‐2‐induced cervical lesion. Cotton tampons saturated with ultraviolet‐inactivated HSV‐2 were inserted into the vaginas of BALB/c mice twice a week. Histological examination performed at the 48th week revealed cervical intraepithelial neoplasia in a HSV‐2‐exposed mouse and a HSV‐2 plus TPA‐exposed mouse but not in control mice. Although premalignant lesions were induced in the mouse uterine cervices by HSV‐2, there was no evidence of malignancy. These results suggest that HSV‐2 functions as an initiator in the multistep process of cervical carcinogenesis.

Original language	English
Pages (from-to)	379-382
Number of pages	4
Journal	Asia‐Oceania Journal of Obstetrics and Gynaecology
Volume	14
Issue number	3
DOIs	https://doi.org/10.1111/j.1447-0756.1988.tb00120.x
Publication status	Published - Sept 1988

All Science Journal Classification (ASJC) codes

Obstetrics and Gynaecology

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10.1111/j.1447-0756.1988.tb00120.x

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title = "Induction of Cervical Intraepithelial Neoplasia in BALB/c Mice by UV‐Inactivated Herpes Simplex Virus Type 2",

abstract = "The present study was undertaken to investigate the oncogenic potential of herpes simplex virus type 2 (HSV‐2) in the mouse cervix and the effect of tetradecanoyl‐phorbol‐acetate (TPA) on the development of HSV‐2‐induced cervical lesion. Cotton tampons saturated with ultraviolet‐inactivated HSV‐2 were inserted into the vaginas of BALB/c mice twice a week. Histological examination performed at the 48th week revealed cervical intraepithelial neoplasia in a HSV‐2‐exposed mouse and a HSV‐2 plus TPA‐exposed mouse but not in control mice. Although premalignant lesions were induced in the mouse uterine cervices by HSV‐2, there was no evidence of malignancy. These results suggest that HSV‐2 functions as an initiator in the multistep process of cervical carcinogenesis.",

author = "Yoshinobu Hayashi and Nobuo Okabe and Ryoichi Mori and Tsunehisa Kaku and Shirou Mohri and Tsuyoshi Iwasaka and Hajime Sugimori",

year = "1988",

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AU - Hayashi, Yoshinobu

AU - Okabe, Nobuo

AU - Mori, Ryoichi

AU - Kaku, Tsunehisa

AU - Mohri, Shirou

AU - Iwasaka, Tsuyoshi

AU - Sugimori, Hajime

PY - 1988/9

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AB - The present study was undertaken to investigate the oncogenic potential of herpes simplex virus type 2 (HSV‐2) in the mouse cervix and the effect of tetradecanoyl‐phorbol‐acetate (TPA) on the development of HSV‐2‐induced cervical lesion. Cotton tampons saturated with ultraviolet‐inactivated HSV‐2 were inserted into the vaginas of BALB/c mice twice a week. Histological examination performed at the 48th week revealed cervical intraepithelial neoplasia in a HSV‐2‐exposed mouse and a HSV‐2 plus TPA‐exposed mouse but not in control mice. Although premalignant lesions were induced in the mouse uterine cervices by HSV‐2, there was no evidence of malignancy. These results suggest that HSV‐2 functions as an initiator in the multistep process of cervical carcinogenesis.

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Induction of Cervical Intraepithelial Neoplasia in BALB/c Mice by UV‐Inactivated Herpes Simplex Virus Type 2

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All Science Journal Classification (ASJC) codes

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