Induction of chronic inflammatory arthropathy and mesenchymal tumors in rats infected with HTLV-I

Jun-Ichi Kira, Kenji Yamasaki, Ichiro Yamamoto, Hidehiro Mizusawa, Shin Yoshino, Susumu Kusunoki, Tsutomu Yoshida, Yoshio Koyanagi, Yuetsu Tanaka, Yuji Kawano, Minoru Nakamura, Masazumi Tsuneyoshi, Naoki Yamamoto, Takuro Kobayashi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To compare the pathogenicity of HTLV-I derived from patients with HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP) and that from patients with adult T-cell leukemia (ATL), neonatal WKA rats were inoculated with either an HTLV-I-infected T-cell line (Fuk line) newly established from a HAM/TSP patient or MT-2 derived from a patient with ATL. Of 38 rats, 34 developed mesenchymal tumors (89%) only after 14 months of age, irrespective of the cell lines used. The rats inoculated with the Fuk line developed severe arthritis (27%) and anti-type II collagen antibody (64%), and less frequently, paraparesis (7%). Those inoculated with MT-2 developed paraparesis (23%), but not arthritis. Cyclophosphamide (CY) administration to induce immunosuppression in the Fuk line-inoculated rats increased the frequency of paraparesis (70%), but decreased the frequency of tumors (20%). HTLV-I proviral DNA was found in the spinal cord, sciatic nerves, tumors, and joints, whereas pX mRNA was detected in the sciatic nerves and tumors, but not in the spinal cord and joints. As a result, HTLV-I is considered to facilitate development of both chronic inflammatory arthropathy associated with autoimmunity and mesenchymal tumors in rats by experimental infection, and its pathogenicity is likely to be greatly influenced by the host immune state.

Original languageEnglish
Pages (from-to)380-392
Number of pages13
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume16
Issue number5
DOIs
Publication statusPublished - Dec 15 1997

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Human T-lymphotropic virus 1
Joint Diseases
Paraparesis
Tropical Spastic Paraparesis
Adult T Cell Leukemia Lymphoma
Sciatic Nerve
Neoplasms
Arthritis
Virulence
Spinal Cord
Joints
Cell Line
Collagen Type II
Autoimmunity
Cyclophosphamide
Immunosuppression
T-Lymphocytes
Messenger RNA
Antibodies
DNA

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Virology

Cite this

Induction of chronic inflammatory arthropathy and mesenchymal tumors in rats infected with HTLV-I. / Kira, Jun-Ichi; Yamasaki, Kenji; Yamamoto, Ichiro; Mizusawa, Hidehiro; Yoshino, Shin; Kusunoki, Susumu; Yoshida, Tsutomu; Koyanagi, Yoshio; Tanaka, Yuetsu; Kawano, Yuji; Nakamura, Minoru; Tsuneyoshi, Masazumi; Yamamoto, Naoki; Kobayashi, Takuro.

In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, Vol. 16, No. 5, 15.12.1997, p. 380-392.

Research output: Contribution to journalArticle

Kira, J-I, Yamasaki, K, Yamamoto, I, Mizusawa, H, Yoshino, S, Kusunoki, S, Yoshida, T, Koyanagi, Y, Tanaka, Y, Kawano, Y, Nakamura, M, Tsuneyoshi, M, Yamamoto, N & Kobayashi, T 1997, 'Induction of chronic inflammatory arthropathy and mesenchymal tumors in rats infected with HTLV-I', Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, vol. 16, no. 5, pp. 380-392. https://doi.org/10.1097/00042560-199712150-00012
Kira, Jun-Ichi ; Yamasaki, Kenji ; Yamamoto, Ichiro ; Mizusawa, Hidehiro ; Yoshino, Shin ; Kusunoki, Susumu ; Yoshida, Tsutomu ; Koyanagi, Yoshio ; Tanaka, Yuetsu ; Kawano, Yuji ; Nakamura, Minoru ; Tsuneyoshi, Masazumi ; Yamamoto, Naoki ; Kobayashi, Takuro. / Induction of chronic inflammatory arthropathy and mesenchymal tumors in rats infected with HTLV-I. In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 1997 ; Vol. 16, No. 5. pp. 380-392.
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AU - Yamasaki, Kenji

AU - Yamamoto, Ichiro

AU - Mizusawa, Hidehiro

AU - Yoshino, Shin

AU - Kusunoki, Susumu

AU - Yoshida, Tsutomu

AU - Koyanagi, Yoshio

AU - Tanaka, Yuetsu

AU - Kawano, Yuji

AU - Nakamura, Minoru

AU - Tsuneyoshi, Masazumi

AU - Yamamoto, Naoki

AU - Kobayashi, Takuro

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