TY - JOUR
T1 - Induction of food intake by a noradrenergic system using clonidine and fusaric acid in the neonatal chick
AU - Bungo, Takashi
AU - Shimojo, Masataka
AU - Masuda, Yasuhisa
AU - Choi, Yang Ho
AU - Denbow, D. Michael
AU - Furuse, Mitsuhiro
N1 - Funding Information:
This study was supported by a grant-in-aid for scientific research from the Ministry of Education, Science and Culture, Japan.
PY - 1999/5/1
Y1 - 1999/5/1
N2 - To clarify noradrenergic systems on food intake of the neonatal chicks, we examined the effects of i.c.v injection of clonidine (CLON), an α2- receptor agonist, and fusaric (5-butylpicolinic) acid (FA), a dopamine (DA)- β-hydroxylase (DBH) inhibitor. Although a high dose (250 ng) of CLON induced a narcoleptic response and reduced food intake, food intake at 30 min post- injection was enhanced by lower doses (25 and 50 ng) of CLON. Central administration of FA (25, 50 and 100 μg) increased food intake in a dose- dependent fashion. It is suggested that feeding behavior is stimulated by low levels of CLON and decreased by further production of norepinephrine (NE), and FA may play the disturbance of sleeping and then enhance food intake.
AB - To clarify noradrenergic systems on food intake of the neonatal chicks, we examined the effects of i.c.v injection of clonidine (CLON), an α2- receptor agonist, and fusaric (5-butylpicolinic) acid (FA), a dopamine (DA)- β-hydroxylase (DBH) inhibitor. Although a high dose (250 ng) of CLON induced a narcoleptic response and reduced food intake, food intake at 30 min post- injection was enhanced by lower doses (25 and 50 ng) of CLON. Central administration of FA (25, 50 and 100 μg) increased food intake in a dose- dependent fashion. It is suggested that feeding behavior is stimulated by low levels of CLON and decreased by further production of norepinephrine (NE), and FA may play the disturbance of sleeping and then enhance food intake.
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U2 - 10.1016/S0006-8993(99)01299-8
DO - 10.1016/S0006-8993(99)01299-8
M3 - Article
C2 - 10224312
AN - SCOPUS:0033135258
SN - 0006-8993
VL - 826
SP - 313
EP - 316
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 2
ER -