Induction of food intake by a noradrenergic system using clonidine and fusaric acid in the neonatal chick

Takashi Bungo, Masataka Shimojo, Yasuhisa Masuda, Yang Ho Choi, D. Michael Denbow, Mitsuhiro Furuse

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

To clarify noradrenergic systems on food intake of the neonatal chicks, we examined the effects of i.c.v injection of clonidine (CLON), an α2- receptor agonist, and fusaric (5-butylpicolinic) acid (FA), a dopamine (DA)- β-hydroxylase (DBH) inhibitor. Although a high dose (250 ng) of CLON induced a narcoleptic response and reduced food intake, food intake at 30 min post- injection was enhanced by lower doses (25 and 50 ng) of CLON. Central administration of FA (25, 50 and 100 μg) increased food intake in a dose- dependent fashion. It is suggested that feeding behavior is stimulated by low levels of CLON and decreased by further production of norepinephrine (NE), and FA may play the disturbance of sleeping and then enhance food intake.

Original languageEnglish
Pages (from-to)313-316
Number of pages4
JournalBrain Research
Volume826
Issue number2
DOIs
Publication statusPublished - May 1 1999

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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