Induction of germline transcription in the TCRγ, locus by Stat5: Implications for accessibility control by the IL-7 receptor

Sang Kyu Ye, Kazushige Maki, Toshio Kitamura, Shinji Sunaga, Koichi Akashi, Jos Domen, Irving L. Weissman, Tasuku Honjo, Koichi Ikuta

Research output: Contribution to journalArticlepeer-review

105 Citations (Scopus)

Abstract

IL-7 receptor (IL-7R) plays critical roles in lymphocyte development by promoting survival and proliferation and by inducing V(D)J recombination in TCR and Ig loci. Here, we demonstrate that IL-7R-activated Stat5 binds to consensus motifs in the 5' regions of Jγ segments and induces germline transcripts. We also show that a constitutively active form of Stat5 restores V-J recombination of TCRγ genes and partially rescues T cell development from IL-7R(-/-) T cell precursors, especially in favor of γδ T cells. Therefore, this study reveals a potential role of Stat5 in T cell development and also implies that IL-7R may control the accessibility of the TCRγ, locus through Stat5-induced germline transcription.

Original languageEnglish
Pages (from-to)213-223
Number of pages11
JournalImmunity
Volume11
Issue number2
DOIs
Publication statusPublished - Aug 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Induction of germline transcription in the TCRγ, locus by Stat5: Implications for accessibility control by the IL-7 receptor'. Together they form a unique fingerprint.

Cite this