Induction of lethal infection with indigenous Escherichia coli in mice by fluorouracil

K. Nomoto, T. Yokokura, Yasunobu Yoshikai, M. Mitsuyama, K. Nomoto

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    A single administration of fluorouracil (5-FU), a well-used cancer chemotherapeutic agent, at high doses (338-800 mg/kg) to specific pathogen free mice induced a lethal infection with Escherichia coli. The infection was manifested in all the mice treated with 5-FU 7-14 days after administration of the drug, when the number of E. coli in liver reached levels ranging from 10 8 to 10 10 colony-forming units, and the type of the infecting bacteria was limited to E. coli. The infection was accompanied with the increase in the population levels of E. coli in the intestinal tract which reached levels about 10 3 to 10 4 times as high as those of normal mice. Administration of tegafur, a less toxic derivative of 5-FU, to mice at a lethal dose of 1280 mg/kg induced infection with E. coli similar to that induced by 5-FU. Multiple administration of both streptomycin sulfate and cephalothin to mice after treatment with 5-FU protected the mice completely from the lethal infection induced by 5-FU, suggesting that the lethality of 5-FU was due to the indigenous bacterial infection.

    Original languageEnglish
    Pages (from-to)244-247
    Number of pages4
    JournalCanadian Journal of Microbiology
    Volume37
    Issue number3
    DOIs
    Publication statusPublished - Jan 1 1991

    Fingerprint

    Fluorouracil
    Escherichia coli
    Infection
    Escherichia coli Infections
    Tegafur
    Cephalothin
    Specific Pathogen-Free Organisms
    Poisons
    Streptomycin
    Bacterial Infections
    Stem Cells
    Bacteria
    Liver
    Pharmaceutical Preparations
    Population
    Neoplasms

    All Science Journal Classification (ASJC) codes

    • Microbiology
    • Immunology
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Genetics

    Cite this

    Induction of lethal infection with indigenous Escherichia coli in mice by fluorouracil. / Nomoto, K.; Yokokura, T.; Yoshikai, Yasunobu; Mitsuyama, M.; Nomoto, K.

    In: Canadian Journal of Microbiology, Vol. 37, No. 3, 01.01.1991, p. 244-247.

    Research output: Contribution to journalArticle

    Nomoto, K, Yokokura, T, Yoshikai, Y, Mitsuyama, M & Nomoto, K 1991, 'Induction of lethal infection with indigenous Escherichia coli in mice by fluorouracil', Canadian Journal of Microbiology, vol. 37, no. 3, pp. 244-247. https://doi.org/10.1139/m91-037
    Nomoto, K. ; Yokokura, T. ; Yoshikai, Yasunobu ; Mitsuyama, M. ; Nomoto, K. / Induction of lethal infection with indigenous Escherichia coli in mice by fluorouracil. In: Canadian Journal of Microbiology. 1991 ; Vol. 37, No. 3. pp. 244-247.
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