Induction of regulatory properties in dendritic cells by Vα14 NKT cells

Satoshi Kojo, Ken Ichiro Seino, Michishige Harada, Hiroshi Watarai, Hiroshi Wakao, Tetsuro Uchida, Toshinori Nakayama, Masaru Taniguchi

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77 Citations (Scopus)

Abstract

Vα14 NKT cells exhibit various immune regulatory properties in vivo, but their precise mechanisms remain to be solved. In this study, we demonstrate the mechanisms of generation of regulatory dendritic cells (DCs) by stimulation of Vα14 NKT cells in vivo. After repeated injection of α-galactosylceramide (α-GalCer) into mice, splenic DCs acquired properties of regulatory DCs in IL-10-dependent fashion, such as nonmatured phenotypes and increased IL-10 but reduced IL-12 production. The unique cytokine profile in these DCs appears to be regulated by ERK1/2 and IκB NS. These DCs also showed an ability to suppress the development of experimental allergic encephalomyelitis by generating IL-10-producing regulatory CD4 T cells in vivo. These findings contribute to explaining how Vα14 NKT cells regulate the immune responses in vivo.

Original languageEnglish
Pages (from-to)3648-3655
Number of pages8
JournalJournal of Immunology
Volume175
Issue number6
Publication statusPublished - Sep 15 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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    Kojo, S., Seino, K. I., Harada, M., Watarai, H., Wakao, H., Uchida, T., Nakayama, T., & Taniguchi, M. (2005). Induction of regulatory properties in dendritic cells by Vα14 NKT cells. Journal of Immunology, 175(6), 3648-3655.