Infected complex renal cysts during crizotinib therapy in a patient with non-small cell lung cancer positive for ALK rearrangement

Yasuto Yoneshima, Isamu Okamoto, Masako Arimura-Omori, Shinichi Kimura, Noriko Hidaka-Fujimoto, Eiji Iwama, Taishi Harada, Koichi Takayama, Yoichi Nakanishi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Crizotinib is the first clinically available tyrosine kinase inhibitor that targets anaplastic lymphoma kinase (ALK) and is associated with the development of complex renal cysts. We now describe a 39-year-old woman who developed infected complex renal cysts during crizotinib treatment. After 10 months of such treatment, she presented with a high fever and low back pain. Computed tomography findings were consistent with complex renal cysts and perilesional inflammation. Interventions including cyst drainage and antibiotic administration contributed to diagnosis and management of the infected cysts.

Original languageEnglish
Pages (from-to)510-512
Number of pages3
JournalInvestigational New Drugs
Volume33
Issue number2
DOIs
Publication statusPublished - Apr 1 2015

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Non-Small Cell Lung Carcinoma
Cysts
Kidney
Therapeutics
Low Back Pain
Protein-Tyrosine Kinases
Drainage
Fever
Tomography
crizotinib
anaplastic lymphoma kinase
Anti-Bacterial Agents
Inflammation

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology
  • Pharmacology (medical)

Cite this

Infected complex renal cysts during crizotinib therapy in a patient with non-small cell lung cancer positive for ALK rearrangement. / Yoneshima, Yasuto; Okamoto, Isamu; Arimura-Omori, Masako; Kimura, Shinichi; Hidaka-Fujimoto, Noriko; Iwama, Eiji; Harada, Taishi; Takayama, Koichi; Nakanishi, Yoichi.

In: Investigational New Drugs, Vol. 33, No. 2, 01.04.2015, p. 510-512.

Research output: Contribution to journalArticle

Yoneshima, Yasuto ; Okamoto, Isamu ; Arimura-Omori, Masako ; Kimura, Shinichi ; Hidaka-Fujimoto, Noriko ; Iwama, Eiji ; Harada, Taishi ; Takayama, Koichi ; Nakanishi, Yoichi. / Infected complex renal cysts during crizotinib therapy in a patient with non-small cell lung cancer positive for ALK rearrangement. In: Investigational New Drugs. 2015 ; Vol. 33, No. 2. pp. 510-512.
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