Infectious complications after gastric cancer surgery accelerate a rapid hepatic recurrence

Takao Ohtsuka, Yoshihiko Kitajima, Tomohide Takahashi, Seiji Sato, Atsushi Miyoshi, Naohiko Kohya, Kenji Kitahara, Yuji Nakafusa, Kohji Miyazaki

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Background/Aims: Rapid hepatic recurrence is sometimes experienced after gastric or pancreatobiliary cancer surgery. The aim of this study was to investigate the risk factors for the timing of hepatic recurrence. Methodology: The medical records of 20 patients who had hepatic recurrence after either a gastrectomy for gastric cancer (11 patients) or a pancreatoduodenectomy for pancreatobiliary cancer (9 patients) between 2002 and 2007 were retrospectively reviewed. The cumulative recurrence rate of liver metastasis was calculated using the Kaplan-Meier method, and 14 possible factors affecting the rapid hepatic recurrence were analyzed by univariate and multivariate analyses. Results: The median time for the hepatic recurrence after the operation was 4.9 months (range 1 to 20.4 months). Among 14 factors, only postoperative infectious complications significantly accelerated the hepatic recurrence based on a univariate analysis (p=0.049). Two more factors, gastric cancer and preoperative tumor marker elevation, had a tendency to affect the rapid recurrence, but did not show statistical significance (both p=0.06). A multivariate analysis revealed that postoperative infectious complications (p=0.005) and gastric cancer (p=0.04) were significant and independent factors. Five of 11 patients with gastric cancer suffered from postoperative infectious complications, 4 of which were associated with pancreatic leakage after a pancreatosplenectomy, and all 5 patients had hepatic recurrence within 3 months after the operation. Conclusions: Postoperative infectious complications are thus considered to accelerate a rapid hepatic recurrence after a gastrectomy for gastric cancer.

Original languageEnglish
Pages (from-to)1277-1280
Number of pages4
Issue number94-95
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology


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