Infectious complications after gastric cancer surgery accelerate a rapid hepatic recurrence

Ohtsuka Takao, Yoshihiko Kitajima, Tomohide Takahashi, Seiji Sato, Atsushi Miyoshi, Naohiko Kohya, Kenji Kitahara, Yuji Nakafusa, Kohji Miyazaki

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background/Aims: Rapid hepatic recurrence is sometimes experienced after gastric or pancreatobiliary cancer surgery. The aim of this study was to investigate the risk factors for the timing of hepatic recurrence. Methodology: The medical records of 20 patients who had hepatic recurrence after either a gastrectomy for gastric cancer (11 patients) or a pancreatoduodenectomy for pancreatobiliary cancer (9 patients) between 2002 and 2007 were retrospectively reviewed. The cumulative recurrence rate of liver metastasis was calculated using the Kaplan-Meier method, and 14 possible factors affecting the rapid hepatic recurrence were analyzed by univariate and multivariate analyses. Results: The median time for the hepatic recurrence after the operation was 4.9 months (range 1 to 20.4 months). Among 14 factors, only postoperative infectious complications significantly accelerated the hepatic recurrence based on a univariate analysis (p=0.049). Two more factors, gastric cancer and preoperative tumor marker elevation, had a tendency to affect the rapid recurrence, but did not show statistical significance (both p=0.06). A multivariate analysis revealed that postoperative infectious complications (p=0.005) and gastric cancer (p=0.04) were significant and independent factors. Five of 11 patients with gastric cancer suffered from postoperative infectious complications, 4 of which were associated with pancreatic leakage after a pancreatosplenectomy, and all 5 patients had hepatic recurrence within 3 months after the operation. Conclusions: Postoperative infectious complications are thus considered to accelerate a rapid hepatic recurrence after a gastrectomy for gastric cancer.

Original languageEnglish
Pages (from-to)1277-1280
Number of pages4
JournalHepato-gastroenterology
Volume56
Issue number94-95
Publication statusPublished - Dec 18 2009

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Stomach Neoplasms
Recurrence
Liver
Gastrectomy
Multivariate Analysis
Pancreaticoduodenectomy
Tumor Biomarkers
Medical Records
Neoplasms
Stomach
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Takao, O., Kitajima, Y., Takahashi, T., Sato, S., Miyoshi, A., Kohya, N., ... Miyazaki, K. (2009). Infectious complications after gastric cancer surgery accelerate a rapid hepatic recurrence. Hepato-gastroenterology, 56(94-95), 1277-1280.

Infectious complications after gastric cancer surgery accelerate a rapid hepatic recurrence. / Takao, Ohtsuka; Kitajima, Yoshihiko; Takahashi, Tomohide; Sato, Seiji; Miyoshi, Atsushi; Kohya, Naohiko; Kitahara, Kenji; Nakafusa, Yuji; Miyazaki, Kohji.

In: Hepato-gastroenterology, Vol. 56, No. 94-95, 18.12.2009, p. 1277-1280.

Research output: Contribution to journalArticle

Takao, O, Kitajima, Y, Takahashi, T, Sato, S, Miyoshi, A, Kohya, N, Kitahara, K, Nakafusa, Y & Miyazaki, K 2009, 'Infectious complications after gastric cancer surgery accelerate a rapid hepatic recurrence', Hepato-gastroenterology, vol. 56, no. 94-95, pp. 1277-1280.
Takao O, Kitajima Y, Takahashi T, Sato S, Miyoshi A, Kohya N et al. Infectious complications after gastric cancer surgery accelerate a rapid hepatic recurrence. Hepato-gastroenterology. 2009 Dec 18;56(94-95):1277-1280.
Takao, Ohtsuka ; Kitajima, Yoshihiko ; Takahashi, Tomohide ; Sato, Seiji ; Miyoshi, Atsushi ; Kohya, Naohiko ; Kitahara, Kenji ; Nakafusa, Yuji ; Miyazaki, Kohji. / Infectious complications after gastric cancer surgery accelerate a rapid hepatic recurrence. In: Hepato-gastroenterology. 2009 ; Vol. 56, No. 94-95. pp. 1277-1280.
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AU - Miyoshi, Atsushi

AU - Kohya, Naohiko

AU - Kitahara, Kenji

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AU - Miyazaki, Kohji

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