Infiltration of dendritic cells in relation to tumor invasion and lymph node metastasis in human gastric cancer

Shunichi Tsujitani, Yoshihiro Kakeji, Akihiro Watanabe, Shunji Kohnoe, Yoshihiko Maehara, Keizo Sugimachi

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100 Citations (Scopus)

Abstract

The infiltration of dendritic cells determined in 210 patients with gastric carcinoma was investigated from the standpoint of tumor invasion, lymph node metastasis, and prognosis. Dendritic cell infiltration was graded as “slight” and “marked.” The 39% frequency in the marked infiltration group at the mucosal stage did not change in proportion to invasion into the deeper layers. The 5‐year survival rate was 60.4% in patients with marked infiltration and 38.8% in those with slight infiltration, which was statistically different (P < 0.01). The difference in survival rates was only statistically significant in those with cancer emerging from the serosa (P < 0.001). There was a similar incidence of lymph node metastasis between the marked and slight infiltration groups in each grade of tumor invasion. However, marked infiltration of dendritic cells prevented widespread nodal involvement beyond the primary node in cases of advanced carcinoma (P < 0.05). These findings indicate that infiltrating dendritic cells do not prevent the spread of tumor invasion but do prevent nodal involvement; therefore, for patients with a gastric cancer emerging from the serosa, the prognosis will be good.

Original languageEnglish
Pages (from-to)2012-2016
Number of pages5
JournalCancer
Volume66
Issue number9
DOIs
Publication statusPublished - Nov 1 1990

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Dendritic Cells
Stomach Neoplasms
Lymph Nodes
Neoplasm Metastasis
Serous Membrane
Neoplasms
Survival Rate
Carcinoma
Stomach
Incidence

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Infiltration of dendritic cells in relation to tumor invasion and lymph node metastasis in human gastric cancer. / Tsujitani, Shunichi; Kakeji, Yoshihiro; Watanabe, Akihiro; Kohnoe, Shunji; Maehara, Yoshihiko; Sugimachi, Keizo.

In: Cancer, Vol. 66, No. 9, 01.11.1990, p. 2012-2016.

Research output: Contribution to journalArticle

Tsujitani, Shunichi ; Kakeji, Yoshihiro ; Watanabe, Akihiro ; Kohnoe, Shunji ; Maehara, Yoshihiko ; Sugimachi, Keizo. / Infiltration of dendritic cells in relation to tumor invasion and lymph node metastasis in human gastric cancer. In: Cancer. 1990 ; Vol. 66, No. 9. pp. 2012-2016.
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