Inflammation-based prognostic score in patients with living donor liver transplantation for hepatocellular carcinoma

Norifumi Harimoto, Tomoharu Yoshizumi, Tomonari Shimagaki, Akihisa Nagatsu, Takashi Motomura, Noboru Harada, Hirohisa Okabe, Shinji Itoh, Toru Ikegami, Hideaki Uchiyama, Yuji Soejima, Yoshihiko Maehara

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Abstract

Background: Inflammation-besed prognostic score including neutrophil/lymphocyte ratio (NLR), platelet/ lymphocyte ratio (PLR), modified Glasgow prognostic score (mGPS) and prognostic nutritional index (PNI) have prognostic value in various malignancies. Patients and Methods: We retrospectively investigated their prognostic value in 213 patients with living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC). Disease-free survival (DFS) following LDLT was calculated; NLR, PLR, PNI and mGPS values in patients with and without recurrence were compared. Risk factors for HCC recurrence were identified by univariate and multivariate analyses. Results: Both NLR and PLR were significantly increased in patients with recurrence. Multivariate analysis showed that desgamma-carboxy prothrombin (DCP) 300 mAU/ml, NLR 2.66, <3 months between last HCC treatment to LDLT were independent predictors of DFS. Conclusion: Preoperative NLR was an independent, inflammation-based prognostic marker of DFS and was predictive of recurrence following LDLT.

Original languageEnglish
Pages (from-to)5537-5542
Number of pages6
JournalAnticancer research
Volume36
Issue number10
DOIs
Publication statusPublished - Oct 2016

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Harimoto, N., Yoshizumi, T., Shimagaki, T., Nagatsu, A., Motomura, T., Harada, N., Okabe, H., Itoh, S., Ikegami, T., Uchiyama, H., Soejima, Y., & Maehara, Y. (2016). Inflammation-based prognostic score in patients with living donor liver transplantation for hepatocellular carcinoma. Anticancer research, 36(10), 5537-5542. https://doi.org/10.21873/anticanres.11137