TY - JOUR
T1 - Inflammation-based prognostic score in patients with living donor liver transplantation for hepatocellular carcinoma
AU - Harimoto, Norifumi
AU - Yoshizumi, Tomoharu
AU - Shimagaki, Tomonari
AU - Nagatsu, Akihisa
AU - Motomura, Takashi
AU - Harada, Noboru
AU - Okabe, Hirohisa
AU - Itoh, Shinji
AU - Ikegami, Toru
AU - Uchiyama, Hideaki
AU - Soejima, Yuji
AU - Maehara, Yoshihiko
PY - 2016/10
Y1 - 2016/10
N2 - Background: Inflammation-besed prognostic score including neutrophil/lymphocyte ratio (NLR), platelet/ lymphocyte ratio (PLR), modified Glasgow prognostic score (mGPS) and prognostic nutritional index (PNI) have prognostic value in various malignancies. Patients and Methods: We retrospectively investigated their prognostic value in 213 patients with living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC). Disease-free survival (DFS) following LDLT was calculated; NLR, PLR, PNI and mGPS values in patients with and without recurrence were compared. Risk factors for HCC recurrence were identified by univariate and multivariate analyses. Results: Both NLR and PLR were significantly increased in patients with recurrence. Multivariate analysis showed that desgamma-carboxy prothrombin (DCP) 300 mAU/ml, NLR 2.66, <3 months between last HCC treatment to LDLT were independent predictors of DFS. Conclusion: Preoperative NLR was an independent, inflammation-based prognostic marker of DFS and was predictive of recurrence following LDLT.
AB - Background: Inflammation-besed prognostic score including neutrophil/lymphocyte ratio (NLR), platelet/ lymphocyte ratio (PLR), modified Glasgow prognostic score (mGPS) and prognostic nutritional index (PNI) have prognostic value in various malignancies. Patients and Methods: We retrospectively investigated their prognostic value in 213 patients with living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC). Disease-free survival (DFS) following LDLT was calculated; NLR, PLR, PNI and mGPS values in patients with and without recurrence were compared. Risk factors for HCC recurrence were identified by univariate and multivariate analyses. Results: Both NLR and PLR were significantly increased in patients with recurrence. Multivariate analysis showed that desgamma-carboxy prothrombin (DCP) 300 mAU/ml, NLR 2.66, <3 months between last HCC treatment to LDLT were independent predictors of DFS. Conclusion: Preoperative NLR was an independent, inflammation-based prognostic marker of DFS and was predictive of recurrence following LDLT.
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U2 - 10.21873/anticanres.11137
DO - 10.21873/anticanres.11137
M3 - Article
C2 - 27798927
AN - SCOPUS:84991824055
SN - 0250-7005
VL - 36
SP - 5537
EP - 5542
JO - Anticancer Research
JF - Anticancer Research
IS - 10
ER -
