Inflammatory changes in obese adipose tissue

Ayaka Ito, Takayoshi Suganami, Yoshihiro Ogawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Evidence has accumulated suggesting that obesity is a state of chronic, low grade inflammation; it may represent a potential mechanism whereby obesity leads to the metabolic derangements. To understand the molecular mechanism underlying the development of obesity and obesity-related metabolic syndrome, it is of great use to divide the obesity-related 'adipose tissue remodeling' into three phases; 1) adipocyte proliferation and hypertrophy, 2) macrophage infiltration, and 3) adipocyte-macrophage interaction. Elucidation of the molecular mechanism underlying the inflammatory changes in each phase of the obesity-related 'adipose tissue remodeling' may lead to the identification of new therapeutic targets that may reduce obesity-induced inflammatory changes and thus the metabolic syndrome.

Original languageEnglish
Pages (from-to)270-276
Number of pages7
JournalNippon rinsho. Japanese journal of clinical medicine
Volume67
Issue number2
Publication statusPublished - Jan 1 2009
Externally publishedYes

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Adipose Tissue
Obesity
Adipocytes
Macrophages
Hypertrophy
Inflammation

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Inflammatory changes in obese adipose tissue. / Ito, Ayaka; Suganami, Takayoshi; Ogawa, Yoshihiro.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 67, No. 2, 01.01.2009, p. 270-276.

Research output: Contribution to journalArticle

Ito, Ayaka ; Suganami, Takayoshi ; Ogawa, Yoshihiro. / Inflammatory changes in obese adipose tissue. In: Nippon rinsho. Japanese journal of clinical medicine. 2009 ; Vol. 67, No. 2. pp. 270-276.
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