Influence of a circadian-stage-dependent dosing schedule on the pharmacokinetics of isepamicin in humans

Yuji Yoshiyama, Teruaki Kobayashi, Shigehiro Ohdo, Nobuya Ogawa, Michel G. Bergeron, Gaston Labrecque, Denis Beauchamp, Shigeyuki Nakano

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

These experiments were conducted in order to determine the influence of the time of day of drug administration on the pharmacokinetics of isepamicin. Six healthy volunteers were given 400 mg isepamicin IM, on 2 separate occasions, either in the morning (8 AM) or in the evening (8 PM). Within-subject differences in the pharmacokinetic parameters between the morning and evening dosing regimens were evaluated. The plasma concentrations of isepamicin were not significantly different between the morning and evening trials, but significant time-dependent changes were found with a lower elimination rate constant and a longer elimination half-life in patients administered isepamicin at night. Our finding suggests that isepamicin may have the same clinical effects irrespective of whether dosing takes place in the morning or in the evening, but its clearance tends to be depressed when taken in the evening. Therefore, morning therapy is desirable because of possible interference from aminoglycoside toxicity.

Original languageEnglish
Pages (from-to)106-109
Number of pages4
JournalJournal of Infection and Chemotherapy
Volume2
Issue number2
DOIs
Publication statusPublished - Jun 1996

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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