Influence of age and comedication on steady-state clonazepam serum level-dose ratios in japanese epileptic patients

E. Yukawa, M. Satou, T. Nonaka, M. Yukawa, S. Ohdo, S. Higuchi, T. Kuroda, Y. Goto

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Background: In antiepileptic drugs, the marked inter- and intrapatient variability of the level-dose ratio makes it difficult to predict serum concentrations from the administered per kg dose. It is therefore important to identify factors, such as age and comedication, that could contribute to this observed variability. Objective: To investigate the effect of age and comedication on clonazepam (CZP) level-dose (L/D) ratios. Method: A retrospective evaluation of data from 137 epileptic patients who had received clonazepam. Results: The CZP L/D ratio increased slowly with age up to 15 years in patients on monotherapy. Associated antiepileptic therapy affected the CZP L/D ratio, which was significantly reduced in patients on polytherapy as compared to patients on monotherapy. Conclusion: The study therefore suggests that routine monitoring of CZP serum levels is extremely useful, especially in the paediatric age group, and in patients who require associated antiepileptic medication.

Original languageEnglish
Pages (from-to)375-379
Number of pages5
JournalJournal of Clinical Pharmacy and Therapeutics
Volume26
Issue number5
DOIs
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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