Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats

Y. Yoshiyama, S. Nishikawa, T. Sugiyama, T. Kobayashi, H. Shimada, F. Tomonaga, S. Ohdo, N. Ogawa, S. Nakano

Research output: Contribution to journalComment/debate

26 Citations (Scopus)

Abstract

Nephrotoxicity was more marked in rats receiving isepamicin at midlight than at middark. And, the once-daily administration at middark induced a lesser degree of nephrotoxicity than the twice-daily injection, which indicates that the once-daily treatment therapy may have potential value in the clinical use of aminoglycosides.

Original languageEnglish
Pages (from-to)2042-2043
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume37
Issue number9
DOIs
Publication statusPublished - 1993

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Yoshiyama, Y., Nishikawa, S., Sugiyama, T., Kobayashi, T., Shimada, H., Tomonaga, F., Ohdo, S., Ogawa, N., & Nakano, S. (1993). Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats. Antimicrobial Agents and Chemotherapy, 37(9), 2042-2043. https://doi.org/10.1128/AAC.37.9.2042