Influence of common cardiac drugs on gastroesophageal reflux disease

Multicenter questionnaire survey

G. Nakaji, M. Fujihara, Mitsuhiro Fukata, S. Yasuda, Keita Odashiro, Toru Maruyama, Koichi Akashi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Although gastroesophageal reflux disease (GERD) causes noncardiac chest pain mimicking angina peetons, systemic studies surveying the effects of common cardiac drugs on symptomatic GERD are rare. Methods: To investigate the drug- related GER.1), this multicenter trial enrolled 201 consecutive cardiac outpatients (69.7 ±10.5 y) after obtaining written infomied consent. They were assessed using the Frequency Scale for Symptoms of GERD (F-scale) to screen for GERD with a cut-off value of 8.0. Clinical background was obtained from medical records. Gastric medicine was empirically administered at the discretion of the attending physician. F-scale score and incidence of GERI) were analyzed individually in relation to background and prescription. Results: The avenge F-scale score did not correlate with gender, age or underlying diseases. F-scale score was elevated significantly (p - 0.006) by administration of calcium channel blockers to the patients treated with gastric medicine, suggesting that calcium channel blockers exacerbate the possibly preexisting GERD. Incidence of GERD within 2 months after starting warfarin tended to be greater than that at other durations (p = 0.087). Patients showing a high score (≥ 8.0) suggestive of GERD showed a correlation with the combined administration of calcium channel blockers (OR 3.19; 95% CI of 1.01 - 10.11; p = 0.049) and warfarin (OR = 3.05; 95% CI of 1.00- 9.27; p = 0.049) in the best logistic model. Conclusion: Although larger cohort is required, this survey demonstrates that the combination of calcium channel blockers and warfarin is an independent risk factor for GERD.

Original languageEnglish
Pages (from-to)555-563
Number of pages9
JournalInternational Journal of Clinical Pharmacology and Therapeutics
Volume49
Issue number9
DOIs
Publication statusPublished - Sep 2011

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Gastroesophageal Reflux
Calcium Channel Blockers
Pharmaceutical Preparations
Warfarin
Stomach
Medicine
Surveys and Questionnaires
Incidence
Chest Pain
Multicenter Studies
Medical Records
Prescriptions
Outpatients
Logistic Models
Physicians

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Influence of common cardiac drugs on gastroesophageal reflux disease : Multicenter questionnaire survey. / Nakaji, G.; Fujihara, M.; Fukata, Mitsuhiro; Yasuda, S.; Odashiro, Keita; Maruyama, Toru; Akashi, Koichi.

In: International Journal of Clinical Pharmacology and Therapeutics, Vol. 49, No. 9, 09.2011, p. 555-563.

Research output: Contribution to journalArticle

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