Influence Of Dietary Cis and Trans Fats on Dmh-Induced Colon Tumors, Steroid Excretion and Eicosanoid Production in Rats Prone to Colon Cancer

Michihiro Sugano, Midori Watanabe, Katsuko Yoshida, Miyuki Tomioka

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The effect of geometrical isomerism of dietary fats on colon tumorigenesis was studied in male and female rats of a strain prone to colon cancer (Wistar-Furth-Osaka). The rats were fed purified diets containing either partially hydrogenated corn oil (trans fat) or high-oleic safflower (cis fat) at the 5% level for one week and received a single oral dose of 1,2-dimethylhydrazine. The difference in the fatty acid composition of dietary fats was confined solely to the geometry of octadecenoate. An appropriate level of linoleic acid (2% of total energy) was supplied. After about 60 weeks, neither fat-type nor sex-dependent differences in the incidence of colon and small intestinal tumors was observed. The fecal excretion of neutral but not acidic steroids was higher in male rats fed the trans fat than in those fed the cis fat, but the composition remained almost unchanged. Aortic production of prostacyclin and the plasma concentration of thromboxane B2 were not influenced by dietary fats, although these were significantly higher in females, irregardless of the fat source. Thus, trans fat behaved much like the cis fat in various parameters, except for steroid excretion.

Original languageEnglish
Pages (from-to)177-187
Number of pages11
JournalNutrition and Cancer
Volume12
Issue number2
DOIs
Publication statusPublished - Jan 1 1989

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Eicosanoids
Colonic Neoplasms
Colon
Fats
Steroids
Dietary Fats
Neoplasms
Carthamus tinctorius
Isomerism
1,2-Dimethylhydrazine
Thromboxane B2
Corn Oil
Epoprostenol
Linoleic Acid
Sex Characteristics
Carcinogenesis
Fatty Acids
Diet
Incidence

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Oncology
  • Nutrition and Dietetics
  • Cancer Research

Cite this

Influence Of Dietary Cis and Trans Fats on Dmh-Induced Colon Tumors, Steroid Excretion and Eicosanoid Production in Rats Prone to Colon Cancer. / Sugano, Michihiro; Watanabe, Midori; Yoshida, Katsuko; Tomioka, Miyuki.

In: Nutrition and Cancer, Vol. 12, No. 2, 01.01.1989, p. 177-187.

Research output: Contribution to journalArticle

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