Influence of fasting and neuropeptide Y on the suppressive food intake induced by intracerebroventricular injection of glucagon-like peptide-1 in the neonatal chick

Mitsuhiro Furuse, Megumi Matsumoto, Ryoichi Mori, Kunio Sugahara, Koichiro Kano, Shin Hasegawa

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Recently, we have reported that central administration of glucagon- like peptide-I (GLP-1) strongly decreased food intake of chicks. The aim of the present study was to elucidate whether suppressed food intake by central injection of GLP-1 would be modified by an appetite stimulant such as fasting and neuropeptide Y (NPY). Birds (2 days old) were starved for 3 or 6 h and then GLP-1 (0.03 μg/10 μl) or saline was injected by the intracerebroventricular (i.c.v.) route. Birds starved for 6 h ate significantly more food than those starved for 3 h, while irrespective of the time for fasting GLP-1 strongly inhibited food intake as rapidly as 10 min after i.c.v injection. The suppressiye effect on food intake continued until 4 h after injection. Central administration of NPY (2.5 μg/10 μl) greatly enhanced food intake, but co-injection of GLP-1 (0.01, 0.02 or 0.03 μg/10μl) decreased food intake in a dose-dependent fashion. Under GLP-1 (0.03μg/10μl) treatment, whether NPY modifies food intake of chicks in a dose-dependent manner was investigated by co-injection of graded levels of NPY (0.4, 1.0 and 2.5 μg/10 μl). GLP-1 completely inhibited the effect of NPY on food intake without a dose response. These results suggest that central GLP-1 may interact with NPY and may be the most potent inhibitor of food intake in the chicken.

Original languageEnglish
Pages (from-to)289-292
Number of pages4
JournalBrain Research
Volume764
Issue number1-2
DOIs
Publication statusPublished - Aug 1 1997

Fingerprint

Glucagon-Like Peptide 1
Neuropeptide Y
Fasting
Eating
Injections
Birds
Appetite Stimulants
Glucagon-Like Peptides
Chickens
Food

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Influence of fasting and neuropeptide Y on the suppressive food intake induced by intracerebroventricular injection of glucagon-like peptide-1 in the neonatal chick. / Furuse, Mitsuhiro; Matsumoto, Megumi; Mori, Ryoichi; Sugahara, Kunio; Kano, Koichiro; Hasegawa, Shin.

In: Brain Research, Vol. 764, No. 1-2, 01.08.1997, p. 289-292.

Research output: Contribution to journalArticle

Furuse, Mitsuhiro ; Matsumoto, Megumi ; Mori, Ryoichi ; Sugahara, Kunio ; Kano, Koichiro ; Hasegawa, Shin. / Influence of fasting and neuropeptide Y on the suppressive food intake induced by intracerebroventricular injection of glucagon-like peptide-1 in the neonatal chick. In: Brain Research. 1997 ; Vol. 764, No. 1-2. pp. 289-292.
@article{3d1d92edb7e84aeaa6bb0a1a0be02a47,
title = "Influence of fasting and neuropeptide Y on the suppressive food intake induced by intracerebroventricular injection of glucagon-like peptide-1 in the neonatal chick",
abstract = "Recently, we have reported that central administration of glucagon- like peptide-I (GLP-1) strongly decreased food intake of chicks. The aim of the present study was to elucidate whether suppressed food intake by central injection of GLP-1 would be modified by an appetite stimulant such as fasting and neuropeptide Y (NPY). Birds (2 days old) were starved for 3 or 6 h and then GLP-1 (0.03 μg/10 μl) or saline was injected by the intracerebroventricular (i.c.v.) route. Birds starved for 6 h ate significantly more food than those starved for 3 h, while irrespective of the time for fasting GLP-1 strongly inhibited food intake as rapidly as 10 min after i.c.v injection. The suppressiye effect on food intake continued until 4 h after injection. Central administration of NPY (2.5 μg/10 μl) greatly enhanced food intake, but co-injection of GLP-1 (0.01, 0.02 or 0.03 μg/10μl) decreased food intake in a dose-dependent fashion. Under GLP-1 (0.03μg/10μl) treatment, whether NPY modifies food intake of chicks in a dose-dependent manner was investigated by co-injection of graded levels of NPY (0.4, 1.0 and 2.5 μg/10 μl). GLP-1 completely inhibited the effect of NPY on food intake without a dose response. These results suggest that central GLP-1 may interact with NPY and may be the most potent inhibitor of food intake in the chicken.",
author = "Mitsuhiro Furuse and Megumi Matsumoto and Ryoichi Mori and Kunio Sugahara and Koichiro Kano and Shin Hasegawa",
year = "1997",
month = "8",
day = "1",
doi = "10.1016/S0006-8993(97)00623-9",
language = "English",
volume = "764",
pages = "289--292",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Influence of fasting and neuropeptide Y on the suppressive food intake induced by intracerebroventricular injection of glucagon-like peptide-1 in the neonatal chick

AU - Furuse, Mitsuhiro

AU - Matsumoto, Megumi

AU - Mori, Ryoichi

AU - Sugahara, Kunio

AU - Kano, Koichiro

AU - Hasegawa, Shin

PY - 1997/8/1

Y1 - 1997/8/1

N2 - Recently, we have reported that central administration of glucagon- like peptide-I (GLP-1) strongly decreased food intake of chicks. The aim of the present study was to elucidate whether suppressed food intake by central injection of GLP-1 would be modified by an appetite stimulant such as fasting and neuropeptide Y (NPY). Birds (2 days old) were starved for 3 or 6 h and then GLP-1 (0.03 μg/10 μl) or saline was injected by the intracerebroventricular (i.c.v.) route. Birds starved for 6 h ate significantly more food than those starved for 3 h, while irrespective of the time for fasting GLP-1 strongly inhibited food intake as rapidly as 10 min after i.c.v injection. The suppressiye effect on food intake continued until 4 h after injection. Central administration of NPY (2.5 μg/10 μl) greatly enhanced food intake, but co-injection of GLP-1 (0.01, 0.02 or 0.03 μg/10μl) decreased food intake in a dose-dependent fashion. Under GLP-1 (0.03μg/10μl) treatment, whether NPY modifies food intake of chicks in a dose-dependent manner was investigated by co-injection of graded levels of NPY (0.4, 1.0 and 2.5 μg/10 μl). GLP-1 completely inhibited the effect of NPY on food intake without a dose response. These results suggest that central GLP-1 may interact with NPY and may be the most potent inhibitor of food intake in the chicken.

AB - Recently, we have reported that central administration of glucagon- like peptide-I (GLP-1) strongly decreased food intake of chicks. The aim of the present study was to elucidate whether suppressed food intake by central injection of GLP-1 would be modified by an appetite stimulant such as fasting and neuropeptide Y (NPY). Birds (2 days old) were starved for 3 or 6 h and then GLP-1 (0.03 μg/10 μl) or saline was injected by the intracerebroventricular (i.c.v.) route. Birds starved for 6 h ate significantly more food than those starved for 3 h, while irrespective of the time for fasting GLP-1 strongly inhibited food intake as rapidly as 10 min after i.c.v injection. The suppressiye effect on food intake continued until 4 h after injection. Central administration of NPY (2.5 μg/10 μl) greatly enhanced food intake, but co-injection of GLP-1 (0.01, 0.02 or 0.03 μg/10μl) decreased food intake in a dose-dependent fashion. Under GLP-1 (0.03μg/10μl) treatment, whether NPY modifies food intake of chicks in a dose-dependent manner was investigated by co-injection of graded levels of NPY (0.4, 1.0 and 2.5 μg/10 μl). GLP-1 completely inhibited the effect of NPY on food intake without a dose response. These results suggest that central GLP-1 may interact with NPY and may be the most potent inhibitor of food intake in the chicken.

UR - http://www.scopus.com/inward/record.url?scp=0030770640&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030770640&partnerID=8YFLogxK

U2 - 10.1016/S0006-8993(97)00623-9

DO - 10.1016/S0006-8993(97)00623-9

M3 - Article

C2 - 9295227

AN - SCOPUS:0030770640

VL - 764

SP - 289

EP - 292

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -