Influence of inoculum size on MICs for methicillin-susceptible Staphylococcus aureus and methicillin-resistant Staphylococcus aureus on in vitro

Noriko Miyake, Masako Kadowaki, Yoriko Sato, Yoshihiro Eriguchi, Yoji Nagasaki, Yukiko Harada, Yujiro Uchida, Nobuyuki Shimono

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Using 49 clinical methicillin-susceptible Staphylococcus aureus isolates (MSSA) and 54 clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates, we examined the change of MIC using five different inocula (2.5-4×10 2cfu/spot - 2.5-4×10 6cfu/spot). We found the big change of the MIC with the increase of the inoculum size in ampicillin against MSSA, and the change was small in cefazolin, meropenem, ciprofloxacin. For anti-MRSA antibiotics, we found the small change with the increase of the inoculums size in vancomycin and arbekacin, and the middle change in teicoplanin and linezolid against MSSA and MRSA. The data from this study suggest that in serious and high inocula infections caused by S. aureus, the presence of an inoculum effect should be considered in curing.

Original languageEnglish
Pages (from-to)231-237
Number of pages7
JournalJapanese Journal of Antibiotics
Volume64
Issue number4
Publication statusPublished - Aug 2011

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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