Influence of intake of skin milk from cows immunized with intestinal bacterial antigens on onset of renal disease in (NZB x NZW)F1 mice fed ad libitum or restricted in energy intake

S. Murosaki, Yasunobu Yoshikai, Chiharu Kubo, A. Ishida, G. Matsuzaki, T. Sato, K. Endo, K. Nomoto

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    Autoimmune disease-prone (NZB x NZW)F1 (B/W) female mice are a model of human lupus erythematosus. Immune milk, obtained from cows immunized with various intestinal bacterial antigens, was given to B/W mice as a component of diets beginning at 8 wk of age. Diets were fed ad libitum or restricted to 60% of ad libitum energy intake. Controls were fed commercial skim milk. In B/W mice fed ad libitum, the titers of anti-single-stranded DNA antibodies were significantly lower in immune milk-fed mice at 4 and 6 mo of age. Onset of proteinuria was delayed and life span was significantly prolonged by immune milk feeding. Surface phenotypes of the T cells and levels of the responsiveness of lymphocytes to mitogens were not changed by immune milk feeding. The B/W mice restricted to 60% of ad libitum energy intake, which preserved immune responsiveness, had not developed proteinuria by 14 mo of age, irrespective of immune milk feeding or control milk feeding. However, at 10 mo of age, the level of plasma antibodies against intestinal bacteria was significantly higher in energy-restricted mice fed control milk than in those fed immune milk or in mice fed ad libitum.

    Original languageEnglish
    Pages (from-to)1860-1868
    Number of pages9
    JournalJournal of Nutrition
    Volume121
    Issue number11
    DOIs
    Publication statusPublished - Jan 1 1991

    Fingerprint

    Bacterial Antigens
    Energy Intake
    Milk
    Kidney
    Skin
    Proteinuria
    Diet
    Antibodies
    Single-Stranded DNA
    Mitogens
    Autoimmune Diseases
    Lymphocytes
    Bacteria
    T-Lymphocytes
    Phenotype

    All Science Journal Classification (ASJC) codes

    • Medicine (miscellaneous)
    • Nutrition and Dietetics

    Cite this

    Influence of intake of skin milk from cows immunized with intestinal bacterial antigens on onset of renal disease in (NZB x NZW)F1 mice fed ad libitum or restricted in energy intake. / Murosaki, S.; Yoshikai, Yasunobu; Kubo, Chiharu; Ishida, A.; Matsuzaki, G.; Sato, T.; Endo, K.; Nomoto, K.

    In: Journal of Nutrition, Vol. 121, No. 11, 01.01.1991, p. 1860-1868.

    Research output: Contribution to journalArticle

    Murosaki, S. ; Yoshikai, Yasunobu ; Kubo, Chiharu ; Ishida, A. ; Matsuzaki, G. ; Sato, T. ; Endo, K. ; Nomoto, K. / Influence of intake of skin milk from cows immunized with intestinal bacterial antigens on onset of renal disease in (NZB x NZW)F1 mice fed ad libitum or restricted in energy intake. In: Journal of Nutrition. 1991 ; Vol. 121, No. 11. pp. 1860-1868.
    @article{b30e7fc2f33b4fbd93115255ceb0c671,
    title = "Influence of intake of skin milk from cows immunized with intestinal bacterial antigens on onset of renal disease in (NZB x NZW)F1 mice fed ad libitum or restricted in energy intake",
    abstract = "Autoimmune disease-prone (NZB x NZW)F1 (B/W) female mice are a model of human lupus erythematosus. Immune milk, obtained from cows immunized with various intestinal bacterial antigens, was given to B/W mice as a component of diets beginning at 8 wk of age. Diets were fed ad libitum or restricted to 60{\%} of ad libitum energy intake. Controls were fed commercial skim milk. In B/W mice fed ad libitum, the titers of anti-single-stranded DNA antibodies were significantly lower in immune milk-fed mice at 4 and 6 mo of age. Onset of proteinuria was delayed and life span was significantly prolonged by immune milk feeding. Surface phenotypes of the T cells and levels of the responsiveness of lymphocytes to mitogens were not changed by immune milk feeding. The B/W mice restricted to 60{\%} of ad libitum energy intake, which preserved immune responsiveness, had not developed proteinuria by 14 mo of age, irrespective of immune milk feeding or control milk feeding. However, at 10 mo of age, the level of plasma antibodies against intestinal bacteria was significantly higher in energy-restricted mice fed control milk than in those fed immune milk or in mice fed ad libitum.",
    author = "S. Murosaki and Yasunobu Yoshikai and Chiharu Kubo and A. Ishida and G. Matsuzaki and T. Sato and K. Endo and K. Nomoto",
    year = "1991",
    month = "1",
    day = "1",
    doi = "10.1093/jn/121.11.1860",
    language = "English",
    volume = "121",
    pages = "1860--1868",
    journal = "Journal of Nutrition",
    issn = "0022-3166",
    publisher = "American Society for Nutrition",
    number = "11",

    }

    TY - JOUR

    T1 - Influence of intake of skin milk from cows immunized with intestinal bacterial antigens on onset of renal disease in (NZB x NZW)F1 mice fed ad libitum or restricted in energy intake

    AU - Murosaki, S.

    AU - Yoshikai, Yasunobu

    AU - Kubo, Chiharu

    AU - Ishida, A.

    AU - Matsuzaki, G.

    AU - Sato, T.

    AU - Endo, K.

    AU - Nomoto, K.

    PY - 1991/1/1

    Y1 - 1991/1/1

    N2 - Autoimmune disease-prone (NZB x NZW)F1 (B/W) female mice are a model of human lupus erythematosus. Immune milk, obtained from cows immunized with various intestinal bacterial antigens, was given to B/W mice as a component of diets beginning at 8 wk of age. Diets were fed ad libitum or restricted to 60% of ad libitum energy intake. Controls were fed commercial skim milk. In B/W mice fed ad libitum, the titers of anti-single-stranded DNA antibodies were significantly lower in immune milk-fed mice at 4 and 6 mo of age. Onset of proteinuria was delayed and life span was significantly prolonged by immune milk feeding. Surface phenotypes of the T cells and levels of the responsiveness of lymphocytes to mitogens were not changed by immune milk feeding. The B/W mice restricted to 60% of ad libitum energy intake, which preserved immune responsiveness, had not developed proteinuria by 14 mo of age, irrespective of immune milk feeding or control milk feeding. However, at 10 mo of age, the level of plasma antibodies against intestinal bacteria was significantly higher in energy-restricted mice fed control milk than in those fed immune milk or in mice fed ad libitum.

    AB - Autoimmune disease-prone (NZB x NZW)F1 (B/W) female mice are a model of human lupus erythematosus. Immune milk, obtained from cows immunized with various intestinal bacterial antigens, was given to B/W mice as a component of diets beginning at 8 wk of age. Diets were fed ad libitum or restricted to 60% of ad libitum energy intake. Controls were fed commercial skim milk. In B/W mice fed ad libitum, the titers of anti-single-stranded DNA antibodies were significantly lower in immune milk-fed mice at 4 and 6 mo of age. Onset of proteinuria was delayed and life span was significantly prolonged by immune milk feeding. Surface phenotypes of the T cells and levels of the responsiveness of lymphocytes to mitogens were not changed by immune milk feeding. The B/W mice restricted to 60% of ad libitum energy intake, which preserved immune responsiveness, had not developed proteinuria by 14 mo of age, irrespective of immune milk feeding or control milk feeding. However, at 10 mo of age, the level of plasma antibodies against intestinal bacteria was significantly higher in energy-restricted mice fed control milk than in those fed immune milk or in mice fed ad libitum.

    UR - http://www.scopus.com/inward/record.url?scp=0026360183&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0026360183&partnerID=8YFLogxK

    U2 - 10.1093/jn/121.11.1860

    DO - 10.1093/jn/121.11.1860

    M3 - Article

    C2 - 1941193

    AN - SCOPUS:0026360183

    VL - 121

    SP - 1860

    EP - 1868

    JO - Journal of Nutrition

    JF - Journal of Nutrition

    SN - 0022-3166

    IS - 11

    ER -