Influence of ketone body and the inhibition of fatty acid oxidation on the food intake of the chick

K. Sashihara; M. Miyamoto; A. Ohgushi; D. M. Denbow; M. Furuse

doi:10.1080/00071660120055412

Influence of ketone body and the inhibition of fatty acid oxidation on the food intake of the chick

K. Sashihara, M. Miyamoto, A. Ohgushi, D. M. Denbow, M. Furuse

Animal and Marine Bioresource Sciences

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

1. Fatty acid oxidation is known to be involved in the control of food intake in mammals. The effect of fatty acid oxidation on food intake in chickens was studied using a ketone body (β-hydroxybutyrate (β-HB)) and mercaptoacetate (MA) (an inhibitor of fatty acid oxidation). 2. Central and peripheral injection of β-HB decreased food intake in a dose-dependent manner, while low doses of MA had no effect. Higher doses of MA inhibited feeding but also caused mortality. 3. These results indicate that ketone bodies act as an inhibitory signal for food intake in both the central and peripheral nervous systems but that inhibition of fatty acid oxidation may not be associated with feeding behaviour in chicks.

Original language	English
Pages (from-to)	405-408
Number of pages	4
Journal	British Poultry Science
Volume	42
Issue number	3
DOIs	https://doi.org/10.1080/00071660120055412
Publication status	Published - 2001

All Science Journal Classification (ASJC) codes

Food Science
Animal Science and Zoology

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10.1080/00071660120055412

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title = "Influence of ketone body and the inhibition of fatty acid oxidation on the food intake of the chick",

abstract = "1. Fatty acid oxidation is known to be involved in the control of food intake in mammals. The effect of fatty acid oxidation on food intake in chickens was studied using a ketone body (β-hydroxybutyrate (β-HB)) and mercaptoacetate (MA) (an inhibitor of fatty acid oxidation). 2. Central and peripheral injection of β-HB decreased food intake in a dose-dependent manner, while low doses of MA had no effect. Higher doses of MA inhibited feeding but also caused mortality. 3. These results indicate that ketone bodies act as an inhibitory signal for food intake in both the central and peripheral nervous systems but that inhibition of fatty acid oxidation may not be associated with feeding behaviour in chicks.",

author = "K. Sashihara and M. Miyamoto and A. Ohgushi and Denbow, {D. M.} and M. Furuse",

note = "Funding Information: This study was supported by a grant-in-aid for scientific research from the Ministry of Education, Science and Culture, Japan.",

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T1 - Influence of ketone body and the inhibition of fatty acid oxidation on the food intake of the chick

AU - Sashihara, K.

AU - Miyamoto, M.

AU - Ohgushi, A.

AU - Denbow, D. M.

AU - Furuse, M.

N1 - Funding Information: This study was supported by a grant-in-aid for scientific research from the Ministry of Education, Science and Culture, Japan.

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N2 - 1. Fatty acid oxidation is known to be involved in the control of food intake in mammals. The effect of fatty acid oxidation on food intake in chickens was studied using a ketone body (β-hydroxybutyrate (β-HB)) and mercaptoacetate (MA) (an inhibitor of fatty acid oxidation). 2. Central and peripheral injection of β-HB decreased food intake in a dose-dependent manner, while low doses of MA had no effect. Higher doses of MA inhibited feeding but also caused mortality. 3. These results indicate that ketone bodies act as an inhibitory signal for food intake in both the central and peripheral nervous systems but that inhibition of fatty acid oxidation may not be associated with feeding behaviour in chicks.

AB - 1. Fatty acid oxidation is known to be involved in the control of food intake in mammals. The effect of fatty acid oxidation on food intake in chickens was studied using a ketone body (β-hydroxybutyrate (β-HB)) and mercaptoacetate (MA) (an inhibitor of fatty acid oxidation). 2. Central and peripheral injection of β-HB decreased food intake in a dose-dependent manner, while low doses of MA had no effect. Higher doses of MA inhibited feeding but also caused mortality. 3. These results indicate that ketone bodies act as an inhibitory signal for food intake in both the central and peripheral nervous systems but that inhibition of fatty acid oxidation may not be associated with feeding behaviour in chicks.

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Influence of ketone body and the inhibition of fatty acid oxidation on the food intake of the chick

Abstract

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