Influence of lung inflation reflex on vascular capacitance in the systemic circulation

E. Y. Cheng, J. Kay, Sumio Hoka, Z. J. Bosnjak, R. L. Coon, J. L. Seagard, J. P. Kampine

Research output: Contribution to journalArticle

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Abstract

The effects of sustained lung inflation on systemic vascular capacitance (SVC), systemic vascular resistance (SVR), and cardiac sympathetic efferent nerve activity (SENA) were investigated in anesthetized dogs. By use of a total cardiopulmonary bypass, the lungs were inflated to tracheal pressures of 10, 15, and 20 mmHg. Tracheal pressures of 10, 15, and 20 mmHg increased system vascular capacitance by 1.4, 3.1, and 4.3 ml/kg and decreased systemic vascular resistance by 0.11, 0.15, and 0.16 mmHg · kg · min · ml-1, respectively, at low carotid sinus pressure (CSP) of 41 mmHg. SENA showed a concomitant decrease. Bilateral vagotomy attenuated the change in SVR by 69%, SVC by 62%, and SENA by 97% when lungs were inflated to a tracheal pressure of 20 mmHg at a low CSP. These results indicate that lung inflation causes a reflex induced increase in SVC as well as a decrease in both SVR and SENA. The lung inflation reflex is mediated primarily through vagal afferent nerve fibers with a small contribution from other afferent nerve pathways.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume257
Issue number5
Publication statusPublished - Jan 1 1989

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Vascular Capacitance
Economic Inflation
Reflex
Vascular Resistance
Pressure
Lung
Carotid Sinus
Afferent Pathways
Vagotomy
Cardiopulmonary Bypass
Nerve Fibers
Dogs

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Cheng, E. Y., Kay, J., Hoka, S., Bosnjak, Z. J., Coon, R. L., Seagard, J. L., & Kampine, J. P. (1989). Influence of lung inflation reflex on vascular capacitance in the systemic circulation. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 257(5).

Influence of lung inflation reflex on vascular capacitance in the systemic circulation. / Cheng, E. Y.; Kay, J.; Hoka, Sumio; Bosnjak, Z. J.; Coon, R. L.; Seagard, J. L.; Kampine, J. P.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 257, No. 5, 01.01.1989.

Research output: Contribution to journalArticle

Cheng, E. Y. ; Kay, J. ; Hoka, Sumio ; Bosnjak, Z. J. ; Coon, R. L. ; Seagard, J. L. ; Kampine, J. P. / Influence of lung inflation reflex on vascular capacitance in the systemic circulation. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 1989 ; Vol. 257, No. 5.
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