Influence of nanostructure on proliferation and differentiation processes of stem cell

Kazutoshi Kubo, Yukihiro Okamoto, Masaya Yamamoto, Noritada Kaji, Manabu Tokeshi, Yasuhiko Tabata, Yoshinobu Baba

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this work, we used nanometer sized grooves which fabricated by nano imprinting method combined with a sol-gel process and observed the effect of nanostructure on mesenchymal stem cells (MSCs). MSCs on the nanostructures spread along the grooves in the first stage of proliferation, and then aggregated after differentiation to osteoblasts. In addition, the proliferation rate of MSCs on the nanostructures was suppressed compared to that on the flat surfaces. These results indicate that nanostructures change the environment around MSCs and affect the behavior of MSCs.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages181-183
Number of pages3
Publication statusPublished - Dec 1 2010
Externally publishedYes
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: Oct 3 2010Oct 7 2010

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume1

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/3/1010/7/10

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All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

Cite this

Kubo, K., Okamoto, Y., Yamamoto, M., Kaji, N., Tokeshi, M., Tabata, Y., & Baba, Y. (2010). Influence of nanostructure on proliferation and differentiation processes of stem cell. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 181-183). (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 1).