Influence of short-term repeated fasting on the longevity of female (NZB x NZW)F1 mice

Hiroshi Sogawa, Chiharu Kubo

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Caloric restriction in rodents is well known to retard the rate of aging, increase mean and maximum life-spans, and inhibit the occurrence of many age-associated diseases. However, little is known about the influence of short-term repeated fasting on longevity. In this study, female (NZB x NZW)F1 mice were used to test the physiological effect of short-term repeated fasting (4 consecutive days, every 2 weeks). The results showed that fasting mice survived significantly longer than the full-fed mice, in spite of the fasting group having a heavier body weight than the control group. Mean survival times for fasting and control mice were 64.0 ± 15.3 and 47.9 ± 9.4 weeks, respectively. Short-term repeated fasting manipulation was also effective on the prolongation of life-span in autoimmune-prone mice. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)61-71
Number of pages11
JournalMechanisms of Ageing and Development
Volume115
Issue number1-2
DOIs
Publication statusPublished - May 17 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Ageing
  • Developmental Biology

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